Effect of Processing on Residual Buprofezin Levels in Ginseng Products
Abstract
:1. Introduction
2. Materials and Methods
2.1. Field Trials
2.2. Processing Procedures and Sample Preparation
2.3. Reagents and Materials
2.4. Extraction and Purification
2.5. Optimization of Instrumental Analysis
2.6. Matrix Effect
2.7. Limits of Quantitation and Recovery
2.8. Processing and Reduction Factors
2.9. Statistical Analysis
3. Results and Discussion
3.1. Calibration Curve and ME
3.2. Recovery
3.3. Residues in Fresh Ginseng
3.4. Half-Lives and Prediction of the Residual Reduction Period
3.5. Processing and Reduction Factors
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Site | Application No. | Application | ||||
---|---|---|---|---|---|---|
Method | Volume (L ha−1) | Dose (kg a.i. ha−1) | Re-Treatment Interval (d) | Total Applied (kg a.i. ha−1) | ||
I (Yeongju) | 1 | Foliar application | 2016 | 0.252 | - | 0.774 |
2 | Foliar application | 2070 | 0.259 | 10 | ||
3 | Foliar application | 2103 | 0.263 | 10 | ||
II (Geumsan) | 1 | Foliar application | 1646 | 0.206 | - | 0.608 |
2 | Foliar application | 1580 | 0.198 | 10 | ||
3 | Foliar application | 1634 | 0.204 | 10 | ||
III (Goesan) | 1 | Foliar application | 1951 | 0.244 | - | 0.724 |
2 | Foliar application | 1901 | 0.238 | 10 | ||
3 | Foliar application | 1938 | 0.242 | 10 |
<LC Condition> | ||||
---|---|---|---|---|
Instrument | Acquity UPLC H Class System, Waters (Milford, MA, USA) | |||
Column | Acquity UHPLC BEH C18 | |||
Flow rate | 0.3 mL min−1 | |||
Mobile phase | 0.1% (v/v) formic acid in water:0.1% (v/v) formic acid in acetonitrile (1:9, v/v) | |||
Injection volume | 1 μL | |||
<Mass condition> | ||||
Instrument | Triple-quadruple spectrometer, Xevo TQD, Waters (USA) | |||
Source temperature | 150 °C | Cone gas flow rate | 50 L h−1 | |
Capillary voltage | 3.0 kV | Ion source | ESI(+) | |
Desolvation gas | Temperature 200 °C; flow rate 650 L h−1 | Scan type | MRM mode | |
<MRM condition> | ||||
Precursor ion (m/z) | Quantitation ion | Confirmation ion | ||
m/z | Collision energy | m/z | Collision energy | |
306.2 | 116.1 | 15 | 201.1 | 10 |
Ginseng | Fortification Level (mg kg−1) | Mean Value (%, n = 5) | Standard Deviation | Coefficient of Variation (%) |
---|---|---|---|---|
Fresh ginseng | 0.005 | 91.09 | 1.87 | 2.05 |
0.05 | 88.98 | 2.43 | 2.74 | |
0.07 | 88.86 | 2.43 | 2.73 | |
Dried ginseng | 0.005 | 83.85 | 3.15 | 3.75 |
0.05 | 90.98 | 1.51 | 1.66 | |
0.07 | 89.24 | 1.27 | 1.42 | |
Red ginseng | 0.005 | 90.66 | 2.87 | 3.16 |
0.05 | 96.04 | 1.83 | 1.91 | |
0.07 | 97.58 | 1.96 | 2.01 |
Site | Mean Residue (mg kg−1, n = 3) | ||||
---|---|---|---|---|---|
Days after Last Application | |||||
0 | 7 | 14 | 21 | 30 | |
1 | 0.076 b ± 0.005 | 0.018 b ± 0.001 | <LOQ | <LOQ | <LOQ |
2 | 0.163 a ± 0.006 | 0.091 a ± 0.002 | 0.055 ± 0.002 | 0.044 ± 0.002 | 0.014 ± 0.002 |
3 | 0.078 b ± 0.002 | 0.012 b ± 0.000 | <LOQ | <LOQ | <LOQ |
Site | Dried Ginseng | Red Ginseng | ||||
---|---|---|---|---|---|---|
Residue (mg kg−1, n = 3) | SD | CV (%) | Residue (mg kg−1, n = 3) | SD | CV (%) | |
1 | 0.046 b | 0.001 | 1.87 | 0.049 b | 0.002 | 4.69 |
2 | 0.189 a | 0.002 | 0.81 | 0.171 a | 0.003 | 1.74 |
3 | 0.013 c | 0.000 | 2.08 | 0.006 c | 0.000 | 0.90 |
Rep. | Residue (mg kg−1) | Water Content (%) | Yield (%) | Residue Based on Dry Weight (mg kg−1) | Processing Factor | Reduction Factor | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
F | D | R | F | D | R | D | R | F | D | R | D | R | D | R | |
1 | 0.053 | 0.190 | 0.175 | 70.1 | 13.2 | 13.7 | 27.8 | 30.5 | 0.177 | 0.158 | 0.141 | 3.58 | 3.30 | 0.89 | 0.80 |
2 | 0.053 | 0.190 | 0.169 | 70.5 | 12.9 | 13.0 | 28.1 | 31.8 | 0.180 | 0.157 | 0.132 | 3.58 | 3.19 | 0.87 | 0.74 |
3 | 0.057 | 0.187 | 0.170 | 71.1 | 13.8 | 13.5 | 29.0 | 30.0 | 0.197 | 0.154 | 0.138 | 3.28 | 2.98 | 0.78 | 0.70 |
Mean | 0.054 | 0.189 | 0.171 | 70.6 | 13.3 | 13.4 | 28.3 | 30.8 | 0.185 | 0.156 | 0.137 | 3.48 | 3.16 | 0.85 | 0.74 |
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Noh, H.H.; Shin, H.W.; Kim, D.J.; Lee, J.W.; Jo, S.H.; Kim, D.; Kyung, K.S. Effect of Processing on Residual Buprofezin Levels in Ginseng Products. Int. J. Environ. Res. Public Health 2021, 18, 471. https://doi.org/10.3390/ijerph18020471
Noh HH, Shin HW, Kim DJ, Lee JW, Jo SH, Kim D, Kyung KS. Effect of Processing on Residual Buprofezin Levels in Ginseng Products. International Journal of Environmental Research and Public Health. 2021; 18(2):471. https://doi.org/10.3390/ijerph18020471
Chicago/Turabian StyleNoh, Hyun Ho, Hyeon Woo Shin, Dong Ju Kim, Jeong Woo Lee, Seung Hyeon Jo, Danbi Kim, and Kee Sung Kyung. 2021. "Effect of Processing on Residual Buprofezin Levels in Ginseng Products" International Journal of Environmental Research and Public Health 18, no. 2: 471. https://doi.org/10.3390/ijerph18020471