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Article

A Possible Outbreak by Serratia marcescens: Genetic Relatedness between Clinical and Environmental Strains

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Department of Biomedical Science and Human Oncology, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy
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Department of Interdisciplinary Medicine, Microbiology Section, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy
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Department of Biology, University of Bari Aldo Moro, Via Orabona 4, 70125 Bari, Italy
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Neonatology and Intensive Care Neonatal Unit Section, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy
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Department of General Surgery, Gynecology and Anaesthesia—Anaesthesia and Intensive Care Unit II, University Hospital Policlinico of Bari, 70124 Bari, Italy
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Health Management, University Hospital Policlinico of Bari, 70124 Bari, Italy
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Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(18), 9814; https://doi.org/10.3390/ijerph18189814
Received: 15 August 2021 / Revised: 14 September 2021 / Accepted: 16 September 2021 / Published: 17 September 2021
(This article belongs to the Special Issue Environmental Hygiene and Health Promotion)
Serratia marcescens (SM) is a Gram-negative bacterium that is frequently found in the environment. Since 1913, when its pathogenicity was first demonstrated, the number of infections caused by SM has increased. There is ample evidence that SM causes nosocomial infections in immunocompromised or critically ill patients admitted to the intensive care units (ICUs), but also in newborns admitted to neonatal ICUs (NICUs). In this study, we evaluated the possible genetic correlation by PFGE between clinical and environmental SM strains from NICU and ICU and compared the genetic profile of clinical strains with strains isolated from patients admitted to other wards of the same hospital. We found distinct clonally related groups of SM strains circulating among different wards of a large university hospital. In particular, the clonal relationship between clinical and environmental strains in NICU and ICU 1 was highlighted. The identification of clonal relationships between clinical and environmental strains in the wards allowed identification of the epidemic and rapid implementation of adequate measures to stop the spread of SM. View Full-Text
Keywords: Serratia marcescens; outbreak; intensive care unit; neonatal intensive care unit; genetic relatedness; pulsed-field gel electrophoresis; environmental sampling; strains Serratia marcescens; outbreak; intensive care unit; neonatal intensive care unit; genetic relatedness; pulsed-field gel electrophoresis; environmental sampling; strains
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MDPI and ACS Style

Caggiano, G.; Triggiano, F.; Diella, G.; Apollonio, F.; Lopuzzo, M.; Mosca, A.; Stolfa, S.; Pazzani, C.; Oliva, M.; Calia, C.; Laforgia, N.; Dalfino, L.; Barbuti, G.; Stefanizzi, P.; Minicucci, A.M.; De Giglio, O.; Montagna, M.T. A Possible Outbreak by Serratia marcescens: Genetic Relatedness between Clinical and Environmental Strains. Int. J. Environ. Res. Public Health 2021, 18, 9814. https://doi.org/10.3390/ijerph18189814

AMA Style

Caggiano G, Triggiano F, Diella G, Apollonio F, Lopuzzo M, Mosca A, Stolfa S, Pazzani C, Oliva M, Calia C, Laforgia N, Dalfino L, Barbuti G, Stefanizzi P, Minicucci AM, De Giglio O, Montagna MT. A Possible Outbreak by Serratia marcescens: Genetic Relatedness between Clinical and Environmental Strains. International Journal of Environmental Research and Public Health. 2021; 18(18):9814. https://doi.org/10.3390/ijerph18189814

Chicago/Turabian Style

Caggiano, Giuseppina, Francesco Triggiano, Giusy Diella, Francesca Apollonio, Marco Lopuzzo, Adriana Mosca, Stefania Stolfa, Carlo Pazzani, Marta Oliva, Carla Calia, Nicola Laforgia, Lidia Dalfino, Giovanna Barbuti, Pasquale Stefanizzi, Anna M. Minicucci, Osvalda De Giglio, and Maria T. Montagna 2021. "A Possible Outbreak by Serratia marcescens: Genetic Relatedness between Clinical and Environmental Strains" International Journal of Environmental Research and Public Health 18, no. 18: 9814. https://doi.org/10.3390/ijerph18189814

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