Gender Differences in Depression and Quality of Life in Current and Abstinent Ketamine Users
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Assessments
2.2.1. Chinese Version of the Center for Epidemiological Studies-Depression Scale (CES-D)
2.2.2. Taiwan Version of the Brief Version of the World Health Organization Quality of Life Instrument (WHOQOL-BREF)
2.3. Data Analysis
3. Results
3.1. Participant Variables and Level of QoL and Depression
3.2. Gender Difference in the Level of QOL and Depression
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variables | Healthy Controls (N = 102) | Current Ketamine Users without Ketamine Use Disorder (N = 102) | Current Ketamine Users with Ketamine Use Disorder (N = 102) | Abstinent Ketamine Users with Ketamine Use Disorder in a Controlled Environment (N = 102) | p |
---|---|---|---|---|---|
N (%) or Mean (SD) | N (%) or Mean (SD) | N (%) or Mean (SD) | N (%) or Mean (SD) | ||
Gender (male) | 84 (82.35) | 85 (83.33) | 83 (81.37) | 93 (91.18) | 0.194 |
Age (years) | 25.94 (5.30) | 25.10 (5.29) | 25.76 (5.97) | 25.59 (6.79) | 0.765 |
Education (years) | 11.61 (2.03) | 11.54 (2.82) | 11.50(2.00) | 11.06(2.02) | 0.304 |
Severity of depression a | 13.49 (8.70) | 17.21 (9.78) | 25.47 (9.78) | 18.83 (10.01) | <0.001 |
Physical domain of QoL b | 16.07 (1.74) | 14.57 (1.87) | 13.68 (1.65) | 15.52 (2.25) | <0.001 |
Psychological domain of QoL b | 15.63 (2.37) | 13.54 (1.68) | 12.05 (1.40) | 14.76 (2.45) | <0.001 |
Social domain of QoL b | 17.21 (2.21) | 15.80 (2.32) | 14.73 (2.28) | 15.98 (2.66) | <0.001 |
Environmental domain of QoL b | 17.22 (1.54) | 15.41 (2.22) | 14.62 (1.76) | 16.06 (2.34) | <0.001 |
Depression | Physical Domain of QoL | Psychological Domain of QoL | Social Domain of QoL | Environmental Domain of QoL | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Variables | Mean (SD) | p | Mean (SD) | p | Mean (SD) | p | Mean (SD) | p | Mean (SD) | p |
Healthy controls | ||||||||||
Female | 21.72 (11.11) | <0.001 | 14.54 (1.61) | <0.001 | 13.15 (2.15) | <0.001 | 16.00 (2.09) | 0.006 | 16.47 (1.29) | 0.014 |
Male | 11.70 (6.97) | 16.39 (1.59) | 16.17 (2.06) | 17.46 (2.16) | 17.38 (1.54) | |||||
Current ketamine users without ketamine use disorder | ||||||||||
Female | 17.71 (8.45) | 0.368 | 14.96 (2.08) | 0.345 | 13.33 (1.94) | 0.699 | 15.94 (2.51) | 0.812 | 16.47 (2.11) | 0.019 |
Male | 17.11 (10.06) | 14.50 (1.83) | 13.58 (1.64) | 15.78 (2.29) | 15.20 (2.19) | |||||
Current ketamine users with ketamine use disorder | ||||||||||
Female | 28.58 (10.87) | 0.098 | 13.50 (1.67) | 0.653 | 11.93 (1.66) | 0.951 | 15.37 (2.09) | 0.154 | 15.16 (1.41) | 0.108 |
Male | 24.76 (9.44) | 13.72 (1.65) | 12.07 (1.34) | 14.58 (2.31) | 14.50 (1.82) | |||||
Abstinent ketamine users with ketamine use disorder | ||||||||||
Female | 36.00 (7.91) | <0.001 | 13.62 (1.32) | 0.004 | 12.74 (1.90) | 0.009 | 14.67 (1.12) | 0.027 | 14.62 (1.99) | 0.031 |
Male | 17.17 (8.55) | 15.71 (2.24) | 14.95 (2.41) | 16.11 (2.74) | 16.20 (2.33) |
Severity of Depression | Physical Domain of QoL | Psychological Domain of QoL | Social Domain of QoL | Environmental Domain of QoL | |
---|---|---|---|---|---|
Variables | Coefficient | Coefficient | Coefficient | Coefficient | Coefficient |
Gender a | −7.15 *** | 0.80 ** | 1.30 *** | 0.38 | 0.01 |
Age (years) | 0.07 | −0.03 | 0.01 | −0.01 | −0.04 |
Education (years) | 0.14 | 0.04 | −0.01 | −0.01 | 0.06 |
Status of ketamine use b | |||||
Abstinent ketamine users with ketamine use disorder in a controlled environment | 6.08 *** | −0.60 * | −1.00 *** | −1.27 *** | −1.14 *** |
Current ketamine users with ketamine use disorder | 11.95 *** | −2.38 *** | −3.58 *** | −2.48 *** | −2.60 *** |
Current ketamine users without ketamine use disorder | 3.86 ** | −1.52 *** | −2.11 *** | −1.42 *** | −1.84 *** |
Severity of Depression | Physical Domain of QoL | Psychological Domain of QoL | Social Domain of QoL | Environmental Domain of QoL | |
---|---|---|---|---|---|
Variables | Coefficient | Coefficient | Coefficient | Coefficient | Coefficient |
Gender a | −10.00 *** | 1.93 *** | 3.01 *** | 1.46 * | 0.98 ** |
Age (years) | 0.06 | −0.03 | 0.003 | 0.01 | −0.02 |
Education (years) | 0.13 | 0.05 | −0.002 | −0.004 | 0.06 |
Status of ketamine use b | |||||
Abstinent ketamine users with ketamine use disorder in a controlled environment | 14.27 *** | −0.72 | −0.42 | −1.36 | −1.67 * |
Current ketamine users with ketamine use disorder | 6.98 * | −0.99 | −1.22 | −0.64 | −1.25 ** |
Current ketamine users without ketamine use disorder | −3.74 | 0.44 | 0.19 | −0.06 | 0.06 |
Interaction between gender and abstinent ketamine users with ketamine use disorder in a controlled environment | −8.82* | −0.08 | −0.80 | 0.01 | 0.52 |
Interaction between gender and current ketamine users with ketamine use disorder | 6.10 | −1.70** | −2.87 *** | −2.25 ** | −1.65 ** |
Interaction between gender and current ketamine users without ketamine use disorder | 9.23 ** | −2.40 *** | −2.77 *** | −1.62 | −2.28 *** |
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Wang, P.-W.; Yen, C.-F.; Wu, H.-C.; Hsu, C.-Y.; Yang, Y.-Y. Gender Differences in Depression and Quality of Life in Current and Abstinent Ketamine Users. Int. J. Environ. Res. Public Health 2021, 18, 9567. https://doi.org/10.3390/ijerph18189567
Wang P-W, Yen C-F, Wu H-C, Hsu C-Y, Yang Y-Y. Gender Differences in Depression and Quality of Life in Current and Abstinent Ketamine Users. International Journal of Environmental Research and Public Health. 2021; 18(18):9567. https://doi.org/10.3390/ijerph18189567
Chicago/Turabian StyleWang, Peng-Wei, Cheng-Fang Yen, Hung-Chi Wu, Chih-Yao Hsu, and Yu-Yi Yang. 2021. "Gender Differences in Depression and Quality of Life in Current and Abstinent Ketamine Users" International Journal of Environmental Research and Public Health 18, no. 18: 9567. https://doi.org/10.3390/ijerph18189567