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Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort

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Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d’Épidémiologie respiratoire intégrative, CESP, 94807 Villejuif, France
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Herbert Wertheim School of Public Health and Human Longevity Science & Scripps, Institution of Oceanography, UC San Diego, La Jolla, CA 92093, USA
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Santé publique France Direction Santé Environnement Travail, 94415 Saint-Maurice, France
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Population-Based Epidemiological Cohorts Unit, INSERM UMS 11, 94807 Villejuif, France
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Faculty of Medicine, University of Paris, 75006 Paris, France
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APHP Centre—Université de Paris, Hôpital et Institut Cochin, Service de Pneumologie, 75014 Paris, France
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UNIV Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)—UMR_S1085, F-49000 Angers, France
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(17), 9258; https://doi.org/10.3390/ijerph18179258
Received: 8 July 2021 / Revised: 25 August 2021 / Accepted: 27 August 2021 / Published: 2 September 2021
(This article belongs to the Section Environmental Health)
Solvents are used in many workplaces and may be airway irritants but few studies have examined their association with asthma. We studied this question in CONSTANCES (cohort of ‘CONSulTANts des Centres d’Examens de Santé’), a large French cohort. Current asthma and asthma symptom scores were defined by participant-reported respiratory symptoms, asthma medication or attacks, and the sum of 5 symptoms, in the past 12 months, respectively. Lifetime exposures to 5 organic solvents, paints and inks were assessed by questionnaire and a population-based Job-Exposure Matrix (JEM). Cross-sectional associations between exposures and outcomes were evaluated by gender using logistic and negative binomial regressions adjusted for age, smoking habits and body mass index. Analyses included 115,757 adults (54% women, mean age 47 years, 9% current asthma). Self-reported exposure to ≥1 solvent was significantly associated with current asthma in men and women, whereas using the JEM, a significant association was observed only in women. Significant associations between exposures to ≥1 solvent and asthma symptom score were observed for both self-report (mean score ratio, 95%CI, women: 1.36, 1.31–1.42; men: 1.34, 1.30–1.40) and JEM (women: 1.10, 1.07–1.15; men: 1.14, 1.09–1.18). Exposure to specific solvents was significantly associated with higher asthma symptom score. Occupational exposure to solvents should be systematically sought when caring for asthma. View Full-Text
Keywords: current asthma; asthma symptom score; occupational exposure; solvents; job-exposure matrix; population-based cohort current asthma; asthma symptom score; occupational exposure; solvents; job-exposure matrix; population-based cohort
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MDPI and ACS Style

Sit, G.; Letellier, N.; Iwatsubo, Y.; Goldberg, M.; Leynaert, B.; Nadif, R.; Ribet, C.; Roche, N.; Roquelaure, Y.; Varraso, R.; Zins, M.; Descatha, A.; Le Moual, N.; Dumas, O. Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort. Int. J. Environ. Res. Public Health 2021, 18, 9258. https://doi.org/10.3390/ijerph18179258

AMA Style

Sit G, Letellier N, Iwatsubo Y, Goldberg M, Leynaert B, Nadif R, Ribet C, Roche N, Roquelaure Y, Varraso R, Zins M, Descatha A, Le Moual N, Dumas O. Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort. International Journal of Environmental Research and Public Health. 2021; 18(17):9258. https://doi.org/10.3390/ijerph18179258

Chicago/Turabian Style

Sit, Guillaume, Noémie Letellier, Yuriko Iwatsubo, Marcel Goldberg, Bénédicte Leynaert, Rachel Nadif, Céline Ribet, Nicolas Roche, Yves Roquelaure, Raphaëlle Varraso, Marie Zins, Alexis Descatha, Nicole Le Moual, and Orianne Dumas. 2021. "Occupational Exposures to Organic Solvents and Asthma Symptoms in the CONSTANCES Cohort" International Journal of Environmental Research and Public Health 18, no. 17: 9258. https://doi.org/10.3390/ijerph18179258

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