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Article

Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease

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World-Class Research Center “Digital Biodesign and Personalized Healthcare”, IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia
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Department of Bioelementology, KG Razumovsky Moscow State University of Technologies and Management, 109004 Moscow, Russia
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Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY 10461, USA
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Graduate Program in Public Health, Center of Health Sciences, State University of Londrina, Londrina 86057-970, Brazil
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College of Nutrition, Taipei Medical University, Taipei 110, Taiwan
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College of Public Health, Taipei Medical University, Taipei 110, Taiwan
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Laboratory of Molecular Dietetics, IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia
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Centre for Strategic Planning of FMBA of Russia, 123182 Moscow, Russia
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Nutrition Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan
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Research Department, Innlandet Hospital Trust, 2380 Brumunddal, Norway
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Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, 150003 Yaroslavl, Russia
*
Author to whom correspondence should be addressed.
Academic Editors: Anna Błażewicz, Katarzyna Ewa Skórzyńska-Dziduszko and Jacek Baj
Int. J. Environ. Res. Public Health 2021, 18(15), 8195; https://doi.org/10.3390/ijerph18158195
Received: 2 June 2021 / Revised: 29 July 2021 / Accepted: 29 July 2021 / Published: 3 August 2021
The objective of the present study was to evaluate hair toxic metal levels in patients with obesity and/or coronary heart disease (CHD). Following a 2 × 2 factorial design, subjects without CHD were grouped into normal weight control (n = 123) and obese groups (n = 140). Patients suffering from CHD were divided into normal weight (n = 180) and obese CHD subjects (n = 240). Hair Al, As, Cd, Hg, Ni, and Pb levels were evaluated using inductively-coupled plasma mass-spectrometry. The data demonstrate that hair Al and Hg levels were higher in obese subjects as compared to normal weight controls. Normal weight CHD patients were characterized by significantly higher hair Al, As, Cd, and Pb levels when compared to healthy subjects. The highest hair Al, As, and Pb levels were observed in obese CHD patients, significantly exceeding the respective values in other groups. Factorial analysis revealed significant influence of factorial interaction (CHD*obesity) only for hair Pb content. Given the role of obesity as a risk factor for CHD, it is proposed that increased toxic metal accumulation in obesity may promote further development of cardiovascular diseases. View Full-Text
Keywords: obesity; coronary heart disease; ischemic heart disease; lead; toxicity obesity; coronary heart disease; ischemic heart disease; lead; toxicity
MDPI and ACS Style

Skalny, A.V.; Kopylov, P.Y.; Paoliello, M.M.B.; Chang, J.-S.; Aschner, M.; Bobrovnitsky, I.P.; Chao, J.C.-J.; Aaseth, J.; Chebotarev, S.N.; Tinkov, A.A. Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease. Int. J. Environ. Res. Public Health 2021, 18, 8195. https://doi.org/10.3390/ijerph18158195

AMA Style

Skalny AV, Kopylov PY, Paoliello MMB, Chang J-S, Aschner M, Bobrovnitsky IP, Chao JC-J, Aaseth J, Chebotarev SN, Tinkov AA. Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease. International Journal of Environmental Research and Public Health. 2021; 18(15):8195. https://doi.org/10.3390/ijerph18158195

Chicago/Turabian Style

Skalny, Anatoly V., Philippe Y. Kopylov, Monica M.B. Paoliello, Jung-Su Chang, Michael Aschner, Igor P. Bobrovnitsky, Jane C.-J. Chao, Jan Aaseth, Sergei N. Chebotarev, and Alexey A. Tinkov 2021. "Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease" International Journal of Environmental Research and Public Health 18, no. 15: 8195. https://doi.org/10.3390/ijerph18158195

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