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Article

The Negative Impact of Varicocele on Basic Semen Parameters, Sperm Nuclear DNA Dispersion and Oxidation-Reduction Potential in Semen

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Department of Histology and Developmental Biology, Pomeranian Medical University, 71-210 Szczecin, Poland
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TFP Fertility Vitrolive in Szczecin, 70-483 Szczecin, Poland
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Department of Urology and Oncological Urology, Regional Specialist Hospital in Szczecin, 71-455 Szczecin, Poland
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Department of Urology and Urological Oncology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland
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Department of Perinatology, Obstetrics and Gynecology, Pomeranian Medical University, 72-010 Police, Poland
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Healthcare Center Nowe Orlowo, 81-525 Gdynia, Poland
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Invicta Fertility Clinic, 80-850 Gdansk, Poland
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Department of Urology, Medical University in Gdansk, 80-214 Gdansk, Poland
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Department of Aesthetic Dermatology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland
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Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Jun Yoshinaga
Int. J. Environ. Res. Public Health 2021, 18(11), 5977; https://doi.org/10.3390/ijerph18115977
Received: 29 April 2021 / Revised: 24 May 2021 / Accepted: 1 June 2021 / Published: 2 June 2021
(This article belongs to the Special Issue The Environment and Reproductive Health: Feature Papers)
Since varicocele is so common in infertile men, this study intends to analyse the relationships between varicocele and conventional semen characteristics, sperm nuclear DNA dispersion and oxidation-reduction potential (ORP) in semen. Varicocele-positive and varicocele-negative infertile men (study groups) showed significantly lower standard sperm parameters and higher sperm DNA fragmentation (SDF) and ORP in semen than healthy volunteers and subjects with proven fertility (control groups). A lower proportion of low SDF levels (0–15% SDF) and higher incidence of high SDF levels (>30% SDF), as well as a higher prevalence of high ORP values (>1.37 mV/106 sperm/mL), were found in the study groups vs. the control groups. Moreover, infertile men had significantly lower odds ratios (ORs) for low SDF levels and significantly higher ORs for high SDF levels and high ORP. SDF and ORP were negatively correlated with sperm number, morphology, motility and vitality. Furthermore, a significant positive correlation was found between SDF and ORP. The obtained results suggest that disorders of spermatogenesis may occur in varicocele-related infertility. These abnormalities are manifested not only by reduced standard semen parameters but also by decreased sperm DNA integrity and simultaneously increased oxidative stress in semen. View Full-Text
Keywords: varicocele; infertility; sperm DNA fragmentation; oxidative stress varicocele; infertility; sperm DNA fragmentation; oxidative stress
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MDPI and ACS Style

Gill, K.; Kups, M.; Harasny, P.; Machalowski, T.; Grabowska, M.; Lukaszuk, M.; Matuszewski, M.; Duchnik, E.; Fraczek, M.; Kurpisz, M.; Piasecka, M. The Negative Impact of Varicocele on Basic Semen Parameters, Sperm Nuclear DNA Dispersion and Oxidation-Reduction Potential in Semen. Int. J. Environ. Res. Public Health 2021, 18, 5977. https://doi.org/10.3390/ijerph18115977

AMA Style

Gill K, Kups M, Harasny P, Machalowski T, Grabowska M, Lukaszuk M, Matuszewski M, Duchnik E, Fraczek M, Kurpisz M, Piasecka M. The Negative Impact of Varicocele on Basic Semen Parameters, Sperm Nuclear DNA Dispersion and Oxidation-Reduction Potential in Semen. International Journal of Environmental Research and Public Health. 2021; 18(11):5977. https://doi.org/10.3390/ijerph18115977

Chicago/Turabian Style

Gill, Kamil, Michal Kups, Patryk Harasny, Tomasz Machalowski, Marta Grabowska, Mariusz Lukaszuk, Marcin Matuszewski, Ewa Duchnik, Monika Fraczek, Maciej Kurpisz, and Malgorzata Piasecka. 2021. "The Negative Impact of Varicocele on Basic Semen Parameters, Sperm Nuclear DNA Dispersion and Oxidation-Reduction Potential in Semen" International Journal of Environmental Research and Public Health 18, no. 11: 5977. https://doi.org/10.3390/ijerph18115977

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