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Article

Increased Risk of Sjögren’s Syndrome in Patients with Obsessive-Compulsive Disorder: A Nationwide Population-Based Cohort Study

1
Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
2
College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
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Division of Allergy, Immunology and Rheumatology, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan
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Division of Allergy, Immunology and Rheumatology, Department of Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
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Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
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Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
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Graduate Institute of Integrated Medicine, China Medical University, Taichung 404333, Taiwan
*
Author to whom correspondence should be addressed.
Yi-Jung Chang and Jui-Cheng Tseng were the co first authors.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2021, 18(11), 5936; https://doi.org/10.3390/ijerph18115936
Received: 14 April 2021 / Revised: 26 May 2021 / Accepted: 28 May 2021 / Published: 1 June 2021
(This article belongs to the Section Health Care Sciences & Services)
Obsessive-compulsive disorder (OCD) includes a wide range of symptoms and is often associated with comorbidities. Although psychiatric involvement may be an early manifestation of Sjögren’s syndrome (SS), only a few studies have demonstrated the relationship between OCD and SS. This is a nationwide cohort study identifying the risk of SS in OCD patients. We studied a longitudinal health insurance database for the period from 1999 to 2013. The study group was OCD patients with at least three outpatient visits or one hospitalization. The comparison cohort was matched by age and sex, as well as comorbidities. We calculated the risk of Sjögren’s syndrome using Cox proportional hazard regression models. We performed a propensity score match for confounders and effect modifiers between the two groups. The propensity score probability was estimated through logistic regression. Primary outcome was the incidental SS. A total of 1678 patients with OCD (49% women, mean age: 35.6 years) and 3356 controls were followed up, resulting in 13,077 and 25,856 person-years, respectively. The hazard ratio for developing SS was 3.31 (95% C.I.: 1.74–6.28) in patients with OCD, compared to those without OCD after adjusting for age, sex, and comorbidities. Furthermore, the risk of SS significantly increased over the 2-year follow-up period after OCD diagnosis. We concluded that risk of SS is significantly increased in patients with OCD compared to those without OCD. Clinically, Sjögren’s symptoms in OCD patients should be regularly assessed. View Full-Text
Keywords: obsessive-compulsive disorder; Sjögren’s syndrome; cohort study; NHIRD; database obsessive-compulsive disorder; Sjögren’s syndrome; cohort study; NHIRD; database
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MDPI and ACS Style

Chang, Y.-J.; Tseng, J.-C.; Leong, P.-Y.; Wang, Y.-H.; Wei, J.C.-C. Increased Risk of Sjögren’s Syndrome in Patients with Obsessive-Compulsive Disorder: A Nationwide Population-Based Cohort Study. Int. J. Environ. Res. Public Health 2021, 18, 5936. https://doi.org/10.3390/ijerph18115936

AMA Style

Chang Y-J, Tseng J-C, Leong P-Y, Wang Y-H, Wei JC-C. Increased Risk of Sjögren’s Syndrome in Patients with Obsessive-Compulsive Disorder: A Nationwide Population-Based Cohort Study. International Journal of Environmental Research and Public Health. 2021; 18(11):5936. https://doi.org/10.3390/ijerph18115936

Chicago/Turabian Style

Chang, Yi-Jung, Jui-Cheng Tseng, Pui-Ying Leong, Yu-Hsun Wang, and James C.-C. Wei 2021. "Increased Risk of Sjögren’s Syndrome in Patients with Obsessive-Compulsive Disorder: A Nationwide Population-Based Cohort Study" International Journal of Environmental Research and Public Health 18, no. 11: 5936. https://doi.org/10.3390/ijerph18115936

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