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Qualitative Phenotyping of Obstructive Sleep Apnea and Its Clinical Usefulness for the Sleep Specialist

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Pulmonary Operative Unit, Department of Thoracic Diseases, Morgagni-Pierantoni Hospital, Romagna Health Company, 47121 Forlì, Italy
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Head & Neck Department, Ear Nose Throat (ENT) Unit, Santa Maria delle Croci Hospital, Romagna Health Company, 48121 Ravenna, Italy
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Adelaide Institute for Sleep Health, A. Flinders University. Centre of Research Excellence, Adelaide 5049, Australia
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Lane Fox Unit/Sleep Disorders Centre, Guy’s & St Thomas’ National Health Service (NHS) Foundation Trust, London SE19RT, UK
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Centre of Human & Aerospace Physiological Sciences, Faculty of Life Sciences and Medicine, King’s College, London WC2R 2LS, UK
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Nuffield Health Brentwood, Shenfield Road, Brentwood, Essex CM15 8EH, UK
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Head & Neck Department, ENT & Oral Surgery Unit, Morgagni-Pierantoni/Infermi Hospital, Romagna Health Company, 47121 Forlì, Italy
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Ear Nose and Throat (ENT) Clinic, Special Surgery Department, Arcispedale S. Anna Hospital, Ferrara University, 44124 Ferrara, Italy
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Department of Otolaryngology Head and Neck surgery, S.Orsola-Malpighi University Hospital, 40138 Bologna, Italy
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Pulmonary Operative Unit, Department of Thoracic Diseases, Morgagni-Pierantoni Hospital, Romagna Health Company, 47121 Forlì, Italy
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Department of Respiratory Diseases & Allergy, Aarhus University Hospital, 8200 Aarhus, Denmark
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Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(6), 2058; https://doi.org/10.3390/ijerph17062058
Received: 28 January 2020 / Revised: 12 March 2020 / Accepted: 17 March 2020 / Published: 20 March 2020
(This article belongs to the Special Issue Obstructive Sleep Apnea Syndrome: From Symptoms to Treatment)
Introduction: The anatomical collapsibility of the upper airway, neuromuscular tone and function, sleep–wake and ventilatory control instability, and the arousal threshold all interact and contribute to certain pathophysiologic features that characterize different types of obstructive sleep apnea (OSA). A model of qualitative phenotypizationallowsus to characterize the different pathophysiological traits in OSA patients.Methods: A narrative review was performed, to analyze the available literature evidence, with the purpose of generating a model of qualitative phenotypization to characterize pathophysiological traits in patients with OSA.Results: 96 out of 3829 abstracts were selected for full-text review. Qualitative phenotyping model of OSA:Data concerning the OSA qualitative pathophysiological traits’ measurement can be deducted by means of clinical PSG, grade of OSA severity, and therapeutic level of Continuous Positive Airway Pressure (CPAP) and are reported in the text. This approach would allow qualitative phenotyping with widely accessible methodology in a routine clinical scenario and is of particular interest for the sleep specialist, surgical treatment decision-making, and customized OSA multimodality treatment. View Full-Text
Keywords: obstructive sleep apnea; phenotypization; CPAP; pathophysiological traits obstructive sleep apnea; phenotypization; CPAP; pathophysiological traits
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Bosi, M.; De Vito, A.; Eckert, D.; Steier, J.; Kotecha, B.; Vicini, C.; Poletti, V. Qualitative Phenotyping of Obstructive Sleep Apnea and Its Clinical Usefulness for the Sleep Specialist. Int. J. Environ. Res. Public Health 2020, 17, 2058.

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