Next Article in Journal
The Extent of Psychosocial Distress among Immigrant and Non-Immigrant Homecare Nurses—A Comparative cross Sectional Survey
Previous Article in Journal
Facilitators and Barriers Associated with Uptake of HIV Self-Testing among Men Who Have Sex with Men in Chongqing, China: A Cross-Sectional Survey
Review

Potential Factors Influencing Repeated SARS Outbreaks in China

1
Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, University Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia
2
Genetics and Regenerative Medicine Research Group, Faculty of Medicine & Health Sciences, University Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia
3
Department of Medical Microbiology and Parasitology, University Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia
4
Institute of Health, Kunming Medical University, Kunming 650500, China
5
Eagle Institute of Molecular Medicine, Apex, NC 27523, USA
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(5), 1633; https://doi.org/10.3390/ijerph17051633
Received: 28 January 2020 / Revised: 22 February 2020 / Accepted: 29 February 2020 / Published: 3 March 2020
(This article belongs to the Section Environmental Health)
Within last 17 years two widespread epidemics of severe acute respiratory syndrome (SARS) occurred in China, which were caused by related coronaviruses (CoVs): SARS-CoV and SARS-CoV-2. Although the origin(s) of these viruses are still unknown and their occurrences in nature are mysterious, some general patterns of their pathogenesis and epidemics are noticeable. Both viruses utilize the same receptor—angiotensin-converting enzyme 2 (ACE2)—for invading human bodies. Both epidemics occurred in cold dry winter seasons celebrated with major holidays, and started in regions where dietary consumption of wildlife is a fashion. Thus, if bats were the natural hosts of SARS-CoVs, cold temperature and low humidity in these times might provide conducive environmental conditions for prolonged viral survival in these regions concentrated with bats. The widespread existence of these bat-carried or -released viruses might have an easier time in breaking through human defenses when harsh winter makes human bodies more vulnerable. Once succeeding in making some initial human infections, spreading of the disease was made convenient with increased social gathering and holiday travel. These natural and social factors influenced the general progression and trajectory of the SARS epidemiology. However, some unique factors might also contribute to the origination of SARS in Wuhan. These factors are discussed in different scenarios in order to promote more research for achieving final validation. View Full-Text
Keywords: Wuhan pneumonia; coronavirus; CoV; severe acute respiratory syndrome; SARS; COVID-19; angiotensin-converting enzyme 2; ACE2; SARS-CoV; 2019-nCoV; outbreak; epidemic; epidemiology; infection; drought; bat; green light; red light; wildlife; host; exposure; risk Wuhan pneumonia; coronavirus; CoV; severe acute respiratory syndrome; SARS; COVID-19; angiotensin-converting enzyme 2; ACE2; SARS-CoV; 2019-nCoV; outbreak; epidemic; epidemiology; infection; drought; bat; green light; red light; wildlife; host; exposure; risk
Show Figures

Figure 1

MDPI and ACS Style

Sun, Z.; Thilakavathy, K.; Kumar, S.S.; He, G.; Liu, S.V. Potential Factors Influencing Repeated SARS Outbreaks in China. Int. J. Environ. Res. Public Health 2020, 17, 1633. https://doi.org/10.3390/ijerph17051633

AMA Style

Sun Z, Thilakavathy K, Kumar SS, He G, Liu SV. Potential Factors Influencing Repeated SARS Outbreaks in China. International Journal of Environmental Research and Public Health. 2020; 17(5):1633. https://doi.org/10.3390/ijerph17051633

Chicago/Turabian Style

Sun, Zhong, Karuppiah Thilakavathy, S. S. Kumar, Guozhong He, and Shi V. Liu 2020. "Potential Factors Influencing Repeated SARS Outbreaks in China" International Journal of Environmental Research and Public Health 17, no. 5: 1633. https://doi.org/10.3390/ijerph17051633

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop