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Review

Physical Exercise as a Multimodal Tool for COVID-19: Could It Be Used as a Preventive Strategy?

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Department of Cellular Biology, Histology and Pharmacology, Faculty of Health Sciences, Campus of Soria, University of Valladolid, 42003 Soria, Spain
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Neurobiology Research Group, Faculty of Medicine, University of Valladolid, 47005 Valladolid, Spain
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Cavidito Research Group, Department of Health Sciences, University of Burgos, 09001 Burgos, Spain
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Microbiology Unit of the Santa Bárbara Hospital, Castilla-Léon Health (SACyL), 42003 Soria, Spain
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Department of Nursing, Faculty of Health Sciences, Campus of Soria, University of Valladolid, 42003 Soria, Spain
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Clinical Pharmacology Service, IdISSC, San Carlos Clinical Hospital, 28040 Madrid, Spain
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Department of Biochemistry, Molecular Biology and Physiology, Faculty of Health Sciences, Campus of Soria, University of Valladolid, 42003 Soria, Spain
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(22), 8496; https://doi.org/10.3390/ijerph17228496
Received: 1 October 2020 / Revised: 11 November 2020 / Accepted: 12 November 2020 / Published: 17 November 2020
(This article belongs to the Special Issue Exercise Medicine in Health and Disease)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or coronavirus disease 2019 (COVID-19) is a novel coronavirus not previously recognized in humans until late 2019. On 31 December 2019, a cluster of cases of pneumonia of unspecified etiology was reported to the World Health Organization in China. The availability of adequate SARS-CoV-2 drugs is also limited, and the efficacy and safety of these drugs for COVID-2019 pneumonia patients need to be assessed by further clinical trials. For these reasons, there is a need for other strategies against COVID-19 that are capable of prevention and treatment. Physical exercise has proven to be an effective therapy for most chronic diseases and microbial infections with preventive/therapeutic benefits, considering that exercise involves primary immunological mediators and/or anti-inflammatory properties. This review aimed to provide an insight into how the implementation of a physical exercise program against COVID-19 may be a useful complementary tool for prevention, which can also enhance recovery, improve quality of life, and provide immune protection against SARS-CoV-2 virus infection in the long term. In summary, physical exercise training exerts immunomodulatory effects, controls the viral gateway, modulates inflammation, stimulates nitric oxide synthesis pathways, and establishes control over oxidative stress. View Full-Text
Keywords: COVID-19; physical exercise; health care; immune system; inflammation; oxidative stress; nitric oxide COVID-19; physical exercise; health care; immune system; inflammation; oxidative stress; nitric oxide
MDPI and ACS Style

Fernández-Lázaro, D.; González-Bernal, J.J.; Sánchez-Serrano, N.; Navascués, L.J.; Ascaso-del-Río, A.; Mielgo-Ayuso, J. Physical Exercise as a Multimodal Tool for COVID-19: Could It Be Used as a Preventive Strategy? Int. J. Environ. Res. Public Health 2020, 17, 8496. https://doi.org/10.3390/ijerph17228496

AMA Style

Fernández-Lázaro D, González-Bernal JJ, Sánchez-Serrano N, Navascués LJ, Ascaso-del-Río A, Mielgo-Ayuso J. Physical Exercise as a Multimodal Tool for COVID-19: Could It Be Used as a Preventive Strategy? International Journal of Environmental Research and Public Health. 2020; 17(22):8496. https://doi.org/10.3390/ijerph17228496

Chicago/Turabian Style

Fernández-Lázaro, Diego, Jerónimo J. González-Bernal, Nerea Sánchez-Serrano, Lourdes J. Navascués, Ana Ascaso-del-Río, and Juan Mielgo-Ayuso. 2020. "Physical Exercise as a Multimodal Tool for COVID-19: Could It Be Used as a Preventive Strategy?" International Journal of Environmental Research and Public Health 17, no. 22: 8496. https://doi.org/10.3390/ijerph17228496

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