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Open AccessArticle

Roma Ethnicity and Sex-Specific Associations of Serum Uric Acid with Cardiometabolic and Hepatorenal Health Factors in Eastern Slovakian Population: The HepaMeta Study

1
Department of Medical Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
2
Department of Pathological Physiology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
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2nd Department of Cardiology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
4
Institute of Cardiovascular Diseases, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
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Department of Internal Medicine, AGEL Hospital, Kosice-Saca, 04015 Kosice, Slovakia
6
2nd Department of Internal Medicine, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
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Louis Pasteur University Hospital, 04011 Kosice, Slovakia
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Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
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Department of Health Psychology, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
10
Department of Gynaecology and Obstetrics, Faculty of Medicine, Pavol Jozef Safarik University, 04011 Kosice, Slovakia
*
Author to whom correspondence should be addressed.
HepaMeta Team members are listed in Appendix A.
Int. J. Environ. Res. Public Health 2020, 17(20), 7673; https://doi.org/10.3390/ijerph17207673
Received: 25 September 2020 / Revised: 16 October 2020 / Accepted: 17 October 2020 / Published: 21 October 2020
(This article belongs to the Special Issue Roma Health Disadvantage)
Background: Health characteristics associated with uric acid (UA) in the Roma minority remain less well known. The study sought to determine the ethnicity- and sex-specific associations of serum UA with health factors in Eastern Slovakian Roma and non-Roma populations. Methods: Data from the comparative cross-sectional HepaMeta study conducted in Slovakia in 2011 were used. The study enrolled 452 Roma subjects (35.2% men) and 403 non-Roma individuals (45.9% men) aged 18–55 years. Results: All study parameters differed between the sexes in both the Roma and non-Roma participants (p < 0.05). UA was related to sex with odds ratio for female sex 0.873, 95% CI 0.853–0.893 (p < 0.0001) per 10-unit increase of UA. Average level of UA ± standard deviation was lower in Roma than in non-Roma (226.54 ± 79.8 vs. 259.11 ± 84.53 umol/L; p < 0.0001). The Roma population presented with greater levels of high-sensitivity C-reactive protein (hsCRP) (3.07 ± 4 mg/L vs. 1.98 ± 2.83 mg/L; p < 0.0001) and ferritin in Roma males (403.78 ± 391.84 vs. 302.67 ± 236.26 mg/L; p < 0.0001). Conclusions: Serum UA is sex- and ethnicity specific. Elevated levels of hsCRP and ferritin particularly in Roma males can reflect low-grade systemic inflammation and thus serve as a marker of an increased cardiovascular risk. View Full-Text
Keywords: C-reactive protein; health status; Roma; sex; uric acid C-reactive protein; health status; Roma; sex; uric acid
MDPI and ACS Style

Pallayova, M.; Brenisin, M.; Putrya, A.; Vrsko, M.; Drazilova, S.; Janicko, M.; Marekova, M.; Pella, D.; Geckova, A.M.; Urdzik, P.; Jarcuska, P.; HepaMeta Team. Roma Ethnicity and Sex-Specific Associations of Serum Uric Acid with Cardiometabolic and Hepatorenal Health Factors in Eastern Slovakian Population: The HepaMeta Study. Int. J. Environ. Res. Public Health 2020, 17, 7673. https://doi.org/10.3390/ijerph17207673

AMA Style

Pallayova M, Brenisin M, Putrya A, Vrsko M, Drazilova S, Janicko M, Marekova M, Pella D, Geckova AM, Urdzik P, Jarcuska P, HepaMeta Team. Roma Ethnicity and Sex-Specific Associations of Serum Uric Acid with Cardiometabolic and Hepatorenal Health Factors in Eastern Slovakian Population: The HepaMeta Study. International Journal of Environmental Research and Public Health. 2020; 17(20):7673. https://doi.org/10.3390/ijerph17207673

Chicago/Turabian Style

Pallayova, Maria; Brenisin, Marek; Putrya, Alina; Vrsko, Martin; Drazilova, Sylvia; Janicko, Martin; Marekova, Maria; Pella, Daniel; Geckova, Andrea M.; Urdzik, Peter; Jarcuska, Peter; HepaMeta Team. 2020. "Roma Ethnicity and Sex-Specific Associations of Serum Uric Acid with Cardiometabolic and Hepatorenal Health Factors in Eastern Slovakian Population: The HepaMeta Study" Int. J. Environ. Res. Public Health 17, no. 20: 7673. https://doi.org/10.3390/ijerph17207673

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