Identification of Potential Biomarkers and Related Transcription Factors in Peripheral Blood of Tuberculosis Patients
Abstract
:1. Introduction
2. Material and Methods
2.1. Microarray Data
2.2. Data Processing
2.3. GO and KEGG Pathway Enrichment Analysis
2.4. Protein–Protein Interaction (PPI) Network Construction and Module Analysis
2.5. TFs Regulatory Network of Hub Genes
3. Results
3.1. Identification of DEGs in PBMC from TB Patients
3.2. GO Analysis of DEGs
3.3. PPI Network Construction and Hub Gene Selection
3.4. Module Analysis
3.5. TF Regulatory Network Analysis of 6 Hub Genes
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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TFs | Genes | Count |
---|---|---|
FOXC1 | LRRK2, FYN, GART, CCR7, CXCR5, and FASLG | 6 |
GATA2 | FASLG, GART, LRRK2, CCR7 | 4 |
PRDM1 | CXCR5, CCR7 | 2 |
TP63 | CXCR5, CCR7 | 2 |
PRRX2 | CXCR5, GART | 2 |
RELA | CXCR5, GART | 2 |
YY1 | FYN, CCR7 | 2 |
NFIC | FYN, GART | 2 |
SRF | FYN, GART | 2 |
CEBPB | LRRK2, CCR7 | 2 |
TEAD1 | LRRK2, CCR7 | 2 |
JUND | FASLG, CCR7 | 2 |
FOXL1 | LRRK2, GART | 2 |
HINFP | LRRK2, GART | 2 |
ARID3A | FYN, FASLG | 2 |
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Xie, L.; Chao, X.; Teng, T.; Li, Q.; Xie, J. Identification of Potential Biomarkers and Related Transcription Factors in Peripheral Blood of Tuberculosis Patients. Int. J. Environ. Res. Public Health 2020, 17, 6993. https://doi.org/10.3390/ijerph17196993
Xie L, Chao X, Teng T, Li Q, Xie J. Identification of Potential Biomarkers and Related Transcription Factors in Peripheral Blood of Tuberculosis Patients. International Journal of Environmental Research and Public Health. 2020; 17(19):6993. https://doi.org/10.3390/ijerph17196993
Chicago/Turabian StyleXie, Longxiang, Xiaoyu Chao, Tieshan Teng, Qiming Li, and Jianping Xie. 2020. "Identification of Potential Biomarkers and Related Transcription Factors in Peripheral Blood of Tuberculosis Patients" International Journal of Environmental Research and Public Health 17, no. 19: 6993. https://doi.org/10.3390/ijerph17196993