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Open AccessArticle

Simple, Low-Cost and Long-Lasting Film for Virus Inactivation Using Avian Coronavirus Model as Challenge

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Embrapa Instrumentação, Rua XV de Novembro 1452, São Carlos 13560-970, Brazil
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Embrapa Suínos e Aves, Rodovia BR-153 Km 110, Concórdia 89715-899, Brazil
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Instituto de Química de São Carlos Universidade de São Paulo, Av. Trabalhador São-Carlense 400, São Carlos 13566-590, Brazil
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Laboratório de Virologia Comparada e Ambiental, Instituto Oswaldo Cruz, Fiocruz, Avenida Brasil, 4365, Rio de Janeiro 21040-360, Brazil
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Instituto de Zootecnia-IZ, Centro de Pesquisa de Genética e Reprodução Animal, Rua Heitor Penteado n.56, Nova Odessa 13380-011, Brazil
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Embrapa Pecuária Sudeste, Rodovia Washington Luiz Km 234 s/n, São Carlos 13560-970, Brazil
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Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(18), 6456; https://doi.org/10.3390/ijerph17186456
Received: 4 August 2020 / Revised: 25 August 2020 / Accepted: 27 August 2020 / Published: 4 September 2020
(This article belongs to the Special Issue COVID-19: Prevention, Diagnosis, Therapy and Follow Up)
The COVID-19 infection, caused by SARS-CoV-2, is inequitably distributed and more lethal among populations with lower socioeconomic status. Direct contact with contaminated surfaces has been among the virus sources, as it remains infective up to days. Several disinfectants have been shown to inactivate SARS-CoV-2, but they rapidly evaporate, are flammable or toxic and may be scarce or inexistent for vulnerable populations. Therefore, we are proposing simple, easy to prepare, low-cost and efficient antiviral films, made with a widely available dishwashing detergent, which can be spread on hands and inanimate surfaces and is expected to maintain virucidal activity for longer periods than the current sanitizers. Avian coronavirus (ACoV) was used as model of the challenge to test the antivirus efficacy of the proposed films. Polystyrene petri dishes were covered with a thin layer of detergent formula. After drying, the films were exposed to different virus doses for 10 min and virus infectivity was determined using embryonated chicken eggs, and RNA virus quantification in allantoic fluids by RT-qPCR. The films inactivated the ACoV (ranging from 103.7 to 106.7 EID50), which is chemically and morphologically similar to SARS-CoV-2, and may constitute an excellent alternative to minimize the spread of COVID-19. View Full-Text
Keywords: coronavirus; film; detergent; antiviral; virucide; inactivation; sanitization coronavirus; film; detergent; antiviral; virucide; inactivation; sanitization
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MDPI and ACS Style

Colnago, L.A.; Trevisol, I.M.; Voss Rech, D.; Forato, L.A.; Igreja do Nascimento Mitre, C.; Gagliardi Leite, J.P.; Giglioti, R.; Okino, C.H. Simple, Low-Cost and Long-Lasting Film for Virus Inactivation Using Avian Coronavirus Model as Challenge. Int. J. Environ. Res. Public Health 2020, 17, 6456.

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