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Article

Similarities between the Effects of Prenatal Chlorpyrifos and Valproic Acid on Ultrasonic Vocalization in Infant Wistar Rats

1
Department of Psychology and Health Research Center, University of Almería, Ctra. Sacramento, s/n, 04120 Almería, Spain
2
Department of Health Sciences, Universidad Europea del Atlántico, Calle Isabel Torres, 21, 39011 Santander, Spain
3
Department of Psychology and Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, C/Carretera de Valls, s/n, 43007 Tarragona, Spain
4
Institut de Neurobiologie de la Mediterranée (INMED), INSERM UMR1249, Aix-Marseille University, Parc Scientifique de Luminy BP.13, CEDEX 09, 13273 Marseille, France
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(17), 6376; https://doi.org/10.3390/ijerph17176376
Received: 13 July 2020 / Revised: 25 August 2020 / Accepted: 29 August 2020 / Published: 1 September 2020
(This article belongs to the Special Issue Environmental Exposures and Autism Spectrum Disorders)
Background: In recent years, ultrasonic vocalizations (USV) in pups has become established as a good tool for evaluating behaviors related to communication deficits and emotional states observed in autism spectrum disorder (ASD). Prenatal valproic acid (VPA) exposure leads to impairments and social behavior deficits associated with autism, with the effects of VPA being considered as a reliable animal model of ASD. Some studies also suggest that prenatal exposure to chlorpyrifos (CPF) could enhance autistic-like behaviors. Methods: In order to explore these similarities, in the present study we tested whether prenatal exposure to CPF at GD12.5–14.5 produces effects that are comparable to those produced by prenatal VPA exposure at GD12.5 in infant Wistar rats. Using Deep Squeek software, we evaluated total number of USVs, latency to the first call, mean call duration, principal frequency peak, high frequency peak, and type of calls. Results: Consistent with our hypothesis, we found that exposure to both CPF and VPA leads to a significantly smaller number of calls along with a longer latency to produce the first call. No significant effects were found for the remaining dependent variables. Conclusions: These results suggest that prenatal exposure to CPF could produce certain behaviors that are reminiscent of those observed in ASD patients. View Full-Text
Keywords: autistic spectrum disorder; ultrasonic vocalizations; chlorpyrifos; valproic acid; prenatal exposure; autism; organophosphates autistic spectrum disorder; ultrasonic vocalizations; chlorpyrifos; valproic acid; prenatal exposure; autism; organophosphates
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MDPI and ACS Style

Morales-Navas, M.; Castaño-Castaño, S.; Pérez-Fernández, C.; Sánchez-Gil, A.; Teresa Colomina, M.; Leinekugel, X.; Sánchez-Santed, F. Similarities between the Effects of Prenatal Chlorpyrifos and Valproic Acid on Ultrasonic Vocalization in Infant Wistar Rats. Int. J. Environ. Res. Public Health 2020, 17, 6376. https://doi.org/10.3390/ijerph17176376

AMA Style

Morales-Navas M, Castaño-Castaño S, Pérez-Fernández C, Sánchez-Gil A, Teresa Colomina M, Leinekugel X, Sánchez-Santed F. Similarities between the Effects of Prenatal Chlorpyrifos and Valproic Acid on Ultrasonic Vocalization in Infant Wistar Rats. International Journal of Environmental Research and Public Health. 2020; 17(17):6376. https://doi.org/10.3390/ijerph17176376

Chicago/Turabian Style

Morales-Navas, Miguel, Sergio Castaño-Castaño, Cristian Pérez-Fernández, Ainhoa Sánchez-Gil, María Teresa Colomina, Xavier Leinekugel, and Fernando Sánchez-Santed. 2020. "Similarities between the Effects of Prenatal Chlorpyrifos and Valproic Acid on Ultrasonic Vocalization in Infant Wistar Rats" International Journal of Environmental Research and Public Health 17, no. 17: 6376. https://doi.org/10.3390/ijerph17176376

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