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Time Course of Autonomic Symptoms in Postural Orthostatic Tachycardia Syndrome (POTS) Patients: Two-Year Follow-Up Results

Internal Medicine, Humanitas Clinical and Research Center—IRCCS, Rozzano, 20089 Milan, Italy
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy
Department of Biomedical Sciences for Health, University of Milan, 20122 Milan, Italy
Departamento de Kinesiología, Universidad Católica del Maule, 3605 Talca, Chile
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(16), 5872;
Received: 22 July 2020 / Revised: 7 August 2020 / Accepted: 11 August 2020 / Published: 13 August 2020
Postural orthostatic tachycardia syndrome (POTS) is a multifactorial condition capable of chronically reducing the quality of life and the work ability of patients. The study aim was to assess the burden of autonomic symptoms in a cohort of POTS patients over 2 years. Patients’ clinical profiles were assessed by the 31-item Composite Autonomic Symptom Score questionnaire (COMPASS 31) and a visual analog scale (VAS). One-way ANOVA for repeated measures followed by Dunnett’s post-hoc test were used to compare symptoms at baseline and at 1 and 2 years. Out of 42 enrolled patients, 25 had a 1-year follow-up and 12 had a 2-year follow-up. At baseline, the reported burden of autonomic symptoms was high (overall COMPASS 31 = 49.9 ± 14.3 /100). Main complaints were related to orthostatic intolerance according to both COMPASS 31 and VAS. Fourteen patients were rendered inactive because of symptoms. At 1-year follow-up, a statistically significant improvement in pupillomotor function and overall score was detected by the COMPASS 31. These findings were confirmed at 2 years, together with a significant reduction in quality of life impairment, assessed by VAS. However, these improvements did not change patients’ occupational status. Awareness of POTS diagnosis, patient monitoring, and tailored therapies can help to improve patients’ condition. View Full-Text
Keywords: POTS; syncope; orthostatic hypotension; working POTS; syncope; orthostatic hypotension; working
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Dipaola, F.; Barberi, C.; Castelnuovo, E.; Minonzio, M.; Fornerone, R.; Shiffer, D.; Cairo, B.; Zamuner, A.R.; Barbic, F.; Furlan, R. Time Course of Autonomic Symptoms in Postural Orthostatic Tachycardia Syndrome (POTS) Patients: Two-Year Follow-Up Results. Int. J. Environ. Res. Public Health 2020, 17, 5872.

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