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Review

Clinical and Regulatory Concerns of Biosimilars: A Review of Literature

1
Faculty of Pharmacy, University Ss. Cyril and Methodius, 1000 Skopje, North Macedonia
2
Department of Pharmacy, Faculty of Medicine, University of Prishtina, 10000 Prishtina, Kosovo
3
Department of Pharmacy, University of Huddersfield, Huddersfield, West Yorkshire HD1 3DH, UK
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(16), 5800; https://doi.org/10.3390/ijerph17165800
Received: 29 June 2020 / Revised: 2 August 2020 / Accepted: 3 August 2020 / Published: 11 August 2020
(This article belongs to the Special Issue New Challenges and Crucial Topics for 2030 Public Health)
Although biosimilars have been part of clinical practice for more than a decade, healthcare professionals (HCPs) do not fully accept them. This is because of the perception that biosimilars may not be like their originators in terms of quality, safety, and efficacy. This study aims to evaluate the current knowledge and attitudes of healthcare professionals toward biosimilar prescription, and to elaborate on their concerns. We reviewed the literature using PubMed, Cochrane Library, and Science Direct electronic databases in the period from 2018 to 2020. The knowledge and confidence of healthcare professionals vary between countries, between clinical profiles and between studies. Although most of the healthcare professionals had a positive attitude to prescribing biosimilars, they would still prefer to prescribe them in initial treatment. Generally, HCPs were against multiple switches and substitution of biosimilars at the pharmacy level. HCP’s key concern was interchangeability, with eventual consequences on the clinical outcome of patients. HCPs still approach biosimilars with caution and stigma. HCPs need to have an unbiased coherent understanding of biosimilars at clinical, molecular and regulatory levels. It was also observed that most of their concerns are more theoretical than science-based. Physicians are in an excellent position to accept biosimilars, but they need the additional support of regulatory authorities to approve and take into consideration the available scientific data regarding biosimilars. View Full-Text
Keywords: biosimilars; clinical practice; interchangeability; extrapolation; pharmacovigilance; regulatory; knowledge; confidence; education biosimilars; clinical practice; interchangeability; extrapolation; pharmacovigilance; regulatory; knowledge; confidence; education
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MDPI and ACS Style

Halimi, V.; Daci, A.; Ancevska Netkovska, K.; Suturkova, L.; Babar, Z.-U.-D.; Grozdanova, A. Clinical and Regulatory Concerns of Biosimilars: A Review of Literature. Int. J. Environ. Res. Public Health 2020, 17, 5800. https://doi.org/10.3390/ijerph17165800

AMA Style

Halimi V, Daci A, Ancevska Netkovska K, Suturkova L, Babar Z-U-D, Grozdanova A. Clinical and Regulatory Concerns of Biosimilars: A Review of Literature. International Journal of Environmental Research and Public Health. 2020; 17(16):5800. https://doi.org/10.3390/ijerph17165800

Chicago/Turabian Style

Halimi, Vesa, Armond Daci, Katerina Ancevska Netkovska, Ljubica Suturkova, Zaheer-Ud-Din Babar, and Aleksandra Grozdanova. 2020. "Clinical and Regulatory Concerns of Biosimilars: A Review of Literature" International Journal of Environmental Research and Public Health 17, no. 16: 5800. https://doi.org/10.3390/ijerph17165800

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