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Article

The Effects of Alcohol Consumption on Cardiometabolic Health Outcomes Following Weight Loss in Premenopausal Women with Obesity: A Pilot Randomized Controlled Trial

Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
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Int. J. Environ. Res. Public Health 2020, 17(15), 5302; https://doi.org/10.3390/ijerph17155302
Received: 2 June 2020 / Revised: 17 July 2020 / Accepted: 21 July 2020 / Published: 23 July 2020
(This article belongs to the Special Issue Healthy Lifestyles: Focus on Nutrition and Exercise Interventions)
Alcohol (i.e., ethanol) is consumed regularly by much of the adult population; yet, the health effects associated with its use are not well-characterized. Clinical interventions to investigate the effects of moderate alcohol consumption on metabolic outcomes, including adiposity and cardiovascular risk factors, are limited and have yielded conflicting data. In addition, no study has reported the effects of routine alcohol intake during weight loss in a controlled feeding trial. We present the first randomized controlled pilot trial to investigate the effects of moderate alcohol consumption on metabolic outcomes during weight loss in women with obesity. Both groups consumed 30% energy restricted diets and were randomized to either an ethanol-free control (CTL) group or a group (EtOH) that consumed 35 g ethanol daily for eight weeks. Our findings demonstrate that, despite similar weight loss, the decrease in mean arterial pressure was attenuated in the EtOH group, relative to the CTL group (p = 0.02). In addition, decreases in other outcomes, including visceral adipose tissue (p = 0.23), circulating lipids (triglycerides (p = 0.11) and cholesterol (p = 0.11)), and uric acid (p = 0.07) tended to be attenuated with alcohol consumption. These pilot data provide potential evidence that moderate alcohol consumption may mitigate the beneficial effects of weight loss and support the need for larger Randomized Controlled Trials (RCTs) to better investigate the metabolic effects of moderate alcohol intake in humans. View Full-Text
Keywords: ethanol; alcohol; weight loss; body weight; obesity; triglycerides; visceral fat; cholesterol; uric acid; blood pressure ethanol; alcohol; weight loss; body weight; obesity; triglycerides; visceral fat; cholesterol; uric acid; blood pressure
MDPI and ACS Style

Apolzan, J.W.; Beyl, R.A.; Martin, C.K.; Greenway, F.L.; White, U. The Effects of Alcohol Consumption on Cardiometabolic Health Outcomes Following Weight Loss in Premenopausal Women with Obesity: A Pilot Randomized Controlled Trial. Int. J. Environ. Res. Public Health 2020, 17, 5302. https://doi.org/10.3390/ijerph17155302

AMA Style

Apolzan JW, Beyl RA, Martin CK, Greenway FL, White U. The Effects of Alcohol Consumption on Cardiometabolic Health Outcomes Following Weight Loss in Premenopausal Women with Obesity: A Pilot Randomized Controlled Trial. International Journal of Environmental Research and Public Health. 2020; 17(15):5302. https://doi.org/10.3390/ijerph17155302

Chicago/Turabian Style

Apolzan, John W., Robbie A. Beyl, Corby K. Martin, Frank L. Greenway, and Ursula White. 2020. "The Effects of Alcohol Consumption on Cardiometabolic Health Outcomes Following Weight Loss in Premenopausal Women with Obesity: A Pilot Randomized Controlled Trial" International Journal of Environmental Research and Public Health 17, no. 15: 5302. https://doi.org/10.3390/ijerph17155302

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