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Article

Risk for Irritable Bowel Syndrome in Patients with Helicobacter Pylori Infection: A Nationwide Population-Based Study Cohort Study in Taiwan

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Division of General Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
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Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan
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Teaching Office, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
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School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan
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Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
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Taiwanese Injury Prevention and Safety Promotion Association, Taipei 11490, Taiwan
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Division of Colorectal Surgery, Department of surgery, Tri-service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
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Department of Surgery, Taoyuan Armed Forces General Hospital, Taoyuan 32551, Taiwan
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Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan
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School of Medicine, National Defense Medical Center, Taipei 11490, Taiwan
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Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(10), 3737; https://doi.org/10.3390/ijerph17103737
Received: 21 April 2020 / Revised: 20 May 2020 / Accepted: 21 May 2020 / Published: 25 May 2020
(This article belongs to the Special Issue Global Infectious Diseases and Surveillance and Control Systems)
Background: The association between Helicobacter pylori (H. pylori) infection and the risk of developing irritable bowel syndrome (IBS) has yet to be investigated; thus, we conducted this nationwide cohort study to examine the association in patients from Taiwan. Methods: A total of approximately 2669 individuals with newly diagnosed H. pylori infection and 10,676 age- and sex-matched patients without a diagnosis of H. pylori infection from 2000 to 2013 were identified from Taiwan’s National Health Insurance Research Database. The Kaplan–Meier method was used to determine the cumulative incidence of H. pylori infection in each cohort. Whether the patient underwent H. pylori eradication therapy was also determined. Results: The cumulative incidence of IBS was higher in the H. pylori-infected cohort than in the comparison cohort (log-rank test, p < 0.001). After adjustment for potential confounders, H. pylori infection was associated with a significantly increased risk of IBS (adjusted hazard ratio (aHR) 3.108, p < 0.001). In addition, the H. pylori-infected cohort who did not receive eradication therapy had a higher risk of IBS than the non-H. pylori-infected cohort (adjusted HR 4.16, p < 0.001). The H. pylori-infected cohort who received eradication therapy had a lower risk of IBS than the comparison cohort (adjusted HR 0.464, p = 0.037). Conclusions: Based on a retrospective follow-up, nationwide study in Taiwan, H. pylori infection was associated with an increased risk of IBS; however, aggressive H. pylori infection eradication therapy can also reduce the risk of IBS. Further underlying biological mechanistic research is needed. View Full-Text
Keywords: Helicobacter pylori infection (H. pylori infection); National Health Insurance Research Database (NHIRD); irritable bowel syndrome (IBS); retrospective cohort study Helicobacter pylori infection (H. pylori infection); National Health Insurance Research Database (NHIRD); irritable bowel syndrome (IBS); retrospective cohort study
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MDPI and ACS Style

Liang, C.-M.; Hsu, C.-H.; Chung, C.-H.; Chen, C.-Y.; Wang, L.-Y.; Hsu, S.-D.; Chang, P.-K.; Hong, Z.-J.; Chien, W.-C.; Hu, J.-M. Risk for Irritable Bowel Syndrome in Patients with Helicobacter Pylori Infection: A Nationwide Population-Based Study Cohort Study in Taiwan. Int. J. Environ. Res. Public Health 2020, 17, 3737. https://doi.org/10.3390/ijerph17103737

AMA Style

Liang C-M, Hsu C-H, Chung C-H, Chen C-Y, Wang L-Y, Hsu S-D, Chang P-K, Hong Z-J, Chien W-C, Hu J-M. Risk for Irritable Bowel Syndrome in Patients with Helicobacter Pylori Infection: A Nationwide Population-Based Study Cohort Study in Taiwan. International Journal of Environmental Research and Public Health. 2020; 17(10):3737. https://doi.org/10.3390/ijerph17103737

Chicago/Turabian Style

Liang, Chia-Ming, Chih-Hsiung Hsu, Chi-Hsiang Chung, Chao-Yang Chen, Lin-Yin Wang, Sheng-Der Hsu, Pi-Kai Chang, Zhi-Jie Hong, Wu-Chien Chien, and Je-Ming Hu. 2020. "Risk for Irritable Bowel Syndrome in Patients with Helicobacter Pylori Infection: A Nationwide Population-Based Study Cohort Study in Taiwan" International Journal of Environmental Research and Public Health 17, no. 10: 3737. https://doi.org/10.3390/ijerph17103737

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