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Open AccessArticle

Association Between Gout and Injury Risk: A National Retrospective Cohort Study

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Division of Nephrology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
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Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, New Taipei City 235, Taiwan
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School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
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Department of General Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan
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Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
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Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan
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Division of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan
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School of Medicine, Buddhist Tzu Chi University, Hualien 970, Taiwan
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Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
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School of Medicine, National Defense Medicine, Taipei 114, Taiwan
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Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(10), 3679; https://doi.org/10.3390/ijerph17103679
Received: 5 April 2020 / Revised: 16 May 2020 / Accepted: 19 May 2020 / Published: 23 May 2020
The association between gout and injury remains unclear. This study aimed to investigate the injury risk in patients with gout. Using the Longitudinal Health Insurance Database (LHID) from 2000 to 2010 in Taiwan, patients with gout (group CFG) and those without gout (group C) were enrolled for further analysis. The CFG group was separated into two subgroups (with and without medication) to determine whether the risk of injury was reduced with drug intervention. The follow-up period was defined as the time from the initial diagnosis of gout to the date of injury. A total of 257,442 individuals were enrolled in this study, with 85,814 people in group CFG and 171,628 people in group C. Using Cox regression analysis, group CFG showed a significant increase in the risk of injury. Traffic injuries, poisoning, falls, crushing/cutting/piercing injury, and suicides were prominent among these injuries. Furthermore, when urate-lowing drugs were used to treat the CFG group, there were no significant differences in the occurrence of injury. Patients with gout had an increased risk of injury overall, and drug intervention did not lower the risk of injury in these patients. View Full-Text
Keywords: gout; injury; urate-lowering therapy gout; injury; urate-lowering therapy
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MDPI and ACS Style

Ou, S.-H.; Chou, C.-L.; Lin, C.-W.; Chien, W.-C.; Fang, T.-C.; Lu, K.-C.; Chen, J.-S. Association Between Gout and Injury Risk: A National Retrospective Cohort Study. Int. J. Environ. Res. Public Health 2020, 17, 3679.

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