Clinical Evaluation of Sarcoidosis in Community Members with World Trade Center Dust Exposure
AbstractBackground: Sarcoidosis is a granulomatous disease involving intrathoracic and extrathoracic organs. Genetic and environmental factors, such as exposure to World-Trade Center (WTC) dust after 9/11, may play a role in clinical presentation. Characterization of sarcoidosis in community members with exposure to the WTC dust can provide further insight into the relationship between environmental exposure and sarcoidosis. Methods: Patients with documented sarcoidosis were identified in the WTC Environmental Health Center (EHC), a treatment program for community members. Demographic and clinical data were collected from standardized questionnaires and chart review. Organ involvement was assessed with a standard instrument. Results: Among patients in the WTC EHC, 87 were identified with sarcoidosis after 9/11. Sarcoidosis cases were more likely African-American, local workers, and had more respiratory symptoms, compared with non-sarcoidosis WTC EHC patients. Many (46%) had ≥ Scadding stage 3 on chest imaging, and had reduced lung function measures. Extrathoracic involvement was identified in 33/87 (38%) with a diversity of organs involved. Conclusions: WTC-exposed sarcoidosis in community members is often characterized by severe pulmonary disease and a high rate of diverse extrathoracic involvement. Further analysis is required to characterize the course of disease progression or resolution. View Full-Text
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Hena, K.M.; Murphy, S.; Zhang, Y.; Shao, Y.; Kazeros, A.; Reibman, J. Clinical Evaluation of Sarcoidosis in Community Members with World Trade Center Dust Exposure. Int. J. Environ. Res. Public Health 2019, 16, 1291.
Hena KM, Murphy S, Zhang Y, Shao Y, Kazeros A, Reibman J. Clinical Evaluation of Sarcoidosis in Community Members with World Trade Center Dust Exposure. International Journal of Environmental Research and Public Health. 2019; 16(7):1291.Chicago/Turabian Style
Hena, Kerry M.; Murphy, Scarlett; Zhang, Yian; Shao, Yongzhao; Kazeros, Angeliki; Reibman, Joan. 2019. "Clinical Evaluation of Sarcoidosis in Community Members with World Trade Center Dust Exposure." Int. J. Environ. Res. Public Health 16, no. 7: 1291.
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