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Open AccessCase Report

Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature

1
Pediatric Clinic Fondazione IRCCS Policlinico San Matteo–V.le Golgi, 19 Pavia, Italy
2
Pediatric Clinic–Department of Life, Health and Environmental Sciences–Piazzale Salvatore Tommasi 1, 67100 Coppito (AQ), Italy
3
Pediatric Clinic–Biotechnological and Applied Clinical Sciences Via Vetoio (Coppito 2), 67100 Coppito (AQ), Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(7), 1289; https://doi.org/10.3390/ijerph16071289
Received: 25 February 2019 / Revised: 2 April 2019 / Accepted: 9 April 2019 / Published: 10 April 2019
(This article belongs to the Section Children's Health)
Melkersson–Rosenthal syndrome (MRS) in children is a rare condition, clinically characterised by a triad of synchronous or metachronous symptoms: recurrent peripheral facial palsy, relapsing orofacial oedema, and a fissured tongue; the most recent review published on the topic has reported 30 published patients. The aetiology of this disease is still unclear. However, genetic factors, as well as alterations in immune functions, infections, and allergic reactions have been postulated. We report three children suffering from MRS and perform a literature review of paediatric cases. Taking into account that clinical and laboratoristical criteria for the diagnosis of MRS are lacking, this syndrome is probably underestimated, and we suggest increasing awareness of such a rare syndrome. Close multidisciplinary follow-up of these children with a team composed by paediatricians, neurologists, neuro-ophthalmologists, dermatologists, and otolaryngologists is crucial to guarantee exhaustive management and treatment success, while minimising relapses. View Full-Text
Keywords: Melkersson Rosenthal Syndrome; fissured tongue; peripheral facial palsy Melkersson Rosenthal Syndrome; fissured tongue; peripheral facial palsy
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Savasta, S.; Rossi, A.; Foiadelli, T.; Licari, A.; Elena Perini, A.M.; Farello, G.; Verrotti, A.; Marseglia, G.L. Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature. Int. J. Environ. Res. Public Health 2019, 16, 1289.

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