Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment
Abstract
1. Introduction
2. Methods
2.1. Participant Selection and Enrollment
2.2. Data Processing and Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Demographic and Clinical Characteristics * | WTCHP (n = 73) | Sinai Cancer Registry (n = 949) | p value | ||
---|---|---|---|---|---|
n | % | n | % | ||
Race/Ethnicity | 0.8177 | ||||
White | 41 | 71.9 | 634 | 70.2 | |
Black | 3 | 5.3 | 68 | 7.5 | |
Other | 13 | 22.8 | 201 | 22.3 | |
Gender | <0.0001 | ||||
Female | 16 | 21.9 | 695 | 73.3 | |
Male | 57 | 78.1 | 253 | 26.7 | |
Tumor Size (cm) | Mean (1.4) | SD (1.2) | Mean (1.8) | SD (1.9) | 0.4053 |
Age at Diagnosis | Mean (48.9) | SD (8.0) | Mean (51.0) | SD (16.2) | 0.2252 |
Histology ^ | 0.0363 | ||||
Papillary Carcinoma | 66 | 90.4 | 792 | 83.5 | |
Papillary Adenocarcinoma NOS | (63.6%) | (58.7%) | |||
Papillary Carcinoma Follicular Variant | (28.8%) | (22.0%) | |||
Papillary Microcarcinoma | (3.0%) | (17.7%) | |||
Papillary Carcinoma Columnar Cell | (4.5%) | (1.6%) | |||
Other Adenocarcinoma | 5 | 6.9 | 41 | 4.3 | |
Oxyphilic Adenocarcinoma | (60.0%) | (46.3%) | |||
Follicular Adenocarcinoma | (40.0%) | (53.7%) | |||
Other | 2 | 2.7 | 116 | 12.2 | |
Smoking Status | 0.0385 | ||||
Current Smoker | 3 | 5.1 | 14 | 1.5 | |
Former or Never Smoker | 56 | 94.9 | 925 | 98.5 | |
Marital Status | <0.0001 | ||||
Married or Partnered | 42 | 70.0 | 519 | 59.7 | |
Separated or Divorced | 12 | 20.0 | 56 | 6.4 | |
Single | 3 | 5.0 | 241 | 27.7 | |
Widowed | 3 | 5.0 | 53 | 6.1 |
Exposures and Medical History * | n | % |
---|---|---|
Radiation Exposure | ||
Yes | 8 | 22.9 |
No | 27 | 77.1 |
Family History of Thyroid Issues | ||
Yes | 3 | 8.8 |
No | 31 | 91.2 |
Family History Other Cancer | ||
Yes | 22 | 66.7 |
No | 11 | 33.3 |
Personal History of Another Cancer | ||
Before Thyroid Cancer | 7 | 20.6 |
After Thyroid Cancer or Unknown dx Date | 8 | 23.5 |
No Other Cancer | 19 | 55.9 |
BMI (kg/m2) | ||
<25 | 4 | 11.8 |
25–30 | 15 | 44.1 |
>30 | 15 | 44.1 |
Diagnosis Method | ||
Because of Symptoms | 21 | 61.8 |
Due to Routine Screening or Unrelated Medical Event | 13 | 38.2 |
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Tuminello, S.; van Gerwen, M.A.G.; Genden, E.; Crane, M.; Lieberman-Cribbin, W.; Taioli, E. Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment. Int. J. Environ. Res. Public Health 2019, 16, 1258. https://doi.org/10.3390/ijerph16071258
Tuminello S, van Gerwen MAG, Genden E, Crane M, Lieberman-Cribbin W, Taioli E. Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment. International Journal of Environmental Research and Public Health. 2019; 16(7):1258. https://doi.org/10.3390/ijerph16071258
Chicago/Turabian StyleTuminello, Stephanie, Maaike A. G. van Gerwen, Eric Genden, Michael Crane, Wil Lieberman-Cribbin, and Emanuela Taioli. 2019. "Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment" International Journal of Environmental Research and Public Health 16, no. 7: 1258. https://doi.org/10.3390/ijerph16071258
APA StyleTuminello, S., van Gerwen, M. A. G., Genden, E., Crane, M., Lieberman-Cribbin, W., & Taioli, E. (2019). Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment. International Journal of Environmental Research and Public Health, 16(7), 1258. https://doi.org/10.3390/ijerph16071258