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Open AccessArticle

Chronic Obstructive Pulmonary Disease as a Main Factor of Premature Aging

1
Internal Medicine Department, Hospital of Volos, 38221 Magnesia, Greece
2
Biochemichal Laboratory Department, Hospital of Volos, 38221 Magnesia, Greece
3
Department of Medical Physiology, University of Thessaly Medical School, 41500 Larissa, Greece
4
Department of Cardiology, University of Thessaly Medical School, 41110 Larissa, Greece
5
Respiratory Medicine Department, University of Thessaly Medical School, University Hospital of Larisa, 41110 Larissa, Greece
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(4), 540; https://doi.org/10.3390/ijerph16040540
Received: 9 January 2019 / Revised: 1 February 2019 / Accepted: 8 February 2019 / Published: 13 February 2019
(1) Background: Chronic obstructive pulmonary disease (COPD) is defined as an inflammatory disorder that presents an increasingly prevalent health problem. Accelerated aging has been examined as a pathologic mechanism of many chronic diseases like COPD. We examined whether COPD is combined with accelerated aging, studying two hormones, dehydroepiandrosterone (DHEA) and growth hormone (GH), known to be characteristic biological markers of aging. (2) Methods: Data were collected from 119 participants, 70 (58.8%) COPD patients and 49 (41.2%) from a health control group over the period of 2014–2016 in a spirometry program. Information about their medical history, tobacco use, and blood tests was obtained. (3) Results: The average age of the health control patients was 73.5 years (SD = 5.5), and that of the COPD patients was 75.4 years (SD = 6.9). Both groups were similar in age and sex. A greater proportion of smokers were found in the COPD group (87.1%) versus the control group (36.7%). The majority of COPD patients were classified as STAGE II (51.4%) and STAGE III (37.1%) according to GOLD (Global Initiative for Chronic Obstructive Pulmonary Disease). Levels of DHEA (SD = 17.1) and GH (SD = 0.37) were significantly lower in the COPD group (p < 0.001) compared to those in the controls (SD = 26.3, SD = 0.79). DHEA and GH were more significant and negatively correlated with age. The regression equation of DHEA with age produced a coefficient equal to 1.26. In this study, the difference in DHEA between COPD patients and controls was, on average, 30.2 μg/dL, indicating that the biological age of a COPD patient is on average about 24 years older than that of a control subject of the same age. Similarly, the difference in GH between COPD patients and controls was, on average, 0.42 ng/mL, indicating that the biological age of a COPD patient is on average about 13.1 years older than that of a control subject of the same age. (4) Conclusions: The findings of our study strongly suggest the presence of premature biological aging in COPD patients. Their biological age could actually vary from 13 to 23 years older than non-COPD controls according to DHEA and GH variation. View Full-Text
Keywords: chronic obstructive pulmonary disease; aging; biological marker; dehydroepiandrosterone; DHEA; growth hormone; GH chronic obstructive pulmonary disease; aging; biological marker; dehydroepiandrosterone; DHEA; growth hormone; GH
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MDPI and ACS Style

Karametos, I.; Tsiboli, P.; Togousidis, I.; Hatzoglou, C.; Giamouzis, G.; Gourgoulianis, K.I. Chronic Obstructive Pulmonary Disease as a Main Factor of Premature Aging. Int. J. Environ. Res. Public Health 2019, 16, 540. https://doi.org/10.3390/ijerph16040540

AMA Style

Karametos I, Tsiboli P, Togousidis I, Hatzoglou C, Giamouzis G, Gourgoulianis KI. Chronic Obstructive Pulmonary Disease as a Main Factor of Premature Aging. International Journal of Environmental Research and Public Health. 2019; 16(4):540. https://doi.org/10.3390/ijerph16040540

Chicago/Turabian Style

Karametos, Ilias; Tsiboli, Paraskevi; Togousidis, Ilias; Hatzoglou, Chrisi; Giamouzis, Grigorios; Gourgoulianis, Konstantinos I. 2019. "Chronic Obstructive Pulmonary Disease as a Main Factor of Premature Aging" Int. J. Environ. Res. Public Health 16, no. 4: 540. https://doi.org/10.3390/ijerph16040540

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