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Article

Mood Disorders in Levothyroxine-Treated Hypothyroid Women

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Hospital El Tomillar de Sevilla, Servicio Andaluz de Salud (SAS), 41500 Alcalá de Guadaira, Spain
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Centro de Salud Najera, Servicio Rioja Salud, 26300 Najera, Spain
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Facultad de Fisioterapia y Enfermería y Fisioterapia de Toledo, Universidad de Castilla la Mancha, 45005 Toledo, Spain
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Grupo de Investigación Multidisciplinar en Cuidados, Universidad de Castilla la Mancha, 45005 Toledo, Spain
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Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain
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Facultad de Enfermería de Cuenca, Universidad de Castilla la Mancha, 16071 Cuenca Toledo, Spain
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Grupo de Investigación CESS, Universidad de Castilla la Mancha, 16071 Cuenca, Spain
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(23), 4776; https://doi.org/10.3390/ijerph16234776
Received: 20 October 2019 / Revised: 26 November 2019 / Accepted: 27 November 2019 / Published: 28 November 2019
(This article belongs to the Section Women's Health)
Background: Hypothyroidism has several symptoms (weight gain, arrhythmias, mood changes, etc.). The aims of this study were (1) to assess the prevalence of anxiety and depression in levothyroxine-treated hypothyroid women and in women without hypothyroidism; (2) to identify variables associated with anxiety and depression. Methods: A case-control study was performed with 393 women. Case-group: 153 levothyroxine-treated hypothyroid women. Control-group: 240 women without hypothyroidism. Convenience sampling. Instrument: The Hamilton Hospital Anxiety and Depression Scale (HADS), and a sociodemographic questionnaire. Results: The prevalence of anxiety in levothyroxine-treated hypothyroid women was higher than in women without hypothyroidism (29.4% vs. 16.7%, χ2 p < 0.001). The prevalence of depression in the case group was higher than in the control group (13.1% vs. 4.6%, χ2 p < 0.001). Levothyroxine-treated hypothyroid women were more likely to have anxiety (OR = 2.08, CI: 1.28–3.38) and depression (OR = 3.13, IC = 1.45–6.45). Conclusion: In spite of receiving treatment with levothyroxine, women with hypothyroidism are more likely to have depression and anxiety. Health professionals need to assess the mood of women with hypothyroidism. Although levothyroxine is a good treatment for the symptoms of hypothyroidism, it may not be enough to prevent development or persistence of depression and anxiety by itself. View Full-Text
Keywords: hypothyroidism; mood disorders; levothyroxine; women hypothyroidism; mood disorders; levothyroxine; women
MDPI and ACS Style

Romero-Gómez, B.; Guerrero-Alonso, P.; Carmona-Torres, J.M.; Notario-Pacheco, B.; Cobo-Cuenca, A.I. Mood Disorders in Levothyroxine-Treated Hypothyroid Women. Int. J. Environ. Res. Public Health 2019, 16, 4776. https://doi.org/10.3390/ijerph16234776

AMA Style

Romero-Gómez B, Guerrero-Alonso P, Carmona-Torres JM, Notario-Pacheco B, Cobo-Cuenca AI. Mood Disorders in Levothyroxine-Treated Hypothyroid Women. International Journal of Environmental Research and Public Health. 2019; 16(23):4776. https://doi.org/10.3390/ijerph16234776

Chicago/Turabian Style

Romero-Gómez, Benjamín, Paula Guerrero-Alonso, Juan M. Carmona-Torres, Blanca Notario-Pacheco, and Ana I. Cobo-Cuenca 2019. "Mood Disorders in Levothyroxine-Treated Hypothyroid Women" International Journal of Environmental Research and Public Health 16, no. 23: 4776. https://doi.org/10.3390/ijerph16234776

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