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Open AccessArticle

The Analysis of Bifenox and Dichlobenil Toxicity in Selected Microorganisms and Human Cancer Cells

Division of Chemistry, Biology and Biotechnology, Faculty of Civil Engineering and Environmental Engineering, Bialystok University of Technology, 15-351 Białystok, Poland
Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, 35001 Las Palmas de Gran Canaria, Spain
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(21), 4137;
Received: 19 July 2019 / Revised: 14 October 2019 / Accepted: 24 October 2019 / Published: 27 October 2019
(This article belongs to the Special Issue Toxicology and Public Health)
Bifenox and Dichlobenil belong to the commonly used in Poland in agriculture group of herbicides and their residues are often detected in the environment. They are poorly known regarding their possible carcinogenic and antibacterial effect at the cellular level. Therefore, we decided to study their activity in bacterial strains Aliivibrio fisheri, E. coli, P. aeruginosa, and C. albicans (yeast) and human cancer ZR-75-1 cells. Compounds under study exhibit stimulatory effect on analyzed bacterial strains. The study performed on mammalian cells better reflects the influence of environmental pollutants on human organism, therefore we evaluated the effect of herbicides on ZR-75-1 cells. Cells viability, apoptosis and selected oxidative stress parameters in ZR-75-1 cells were investigated. Both analyzed substances exhibit stimulatory effects on analyzed parameters, however they do not stimulate apoptosis which correlate positively with the induction of oxidative stress. Bifenox and Dichlobenil enhance oxidative stress parameters by the generation of high levels of ROS, which can lead to their adaptation and resistance to the standard treatment regimen. View Full-Text
Keywords: herbicides; bacteria; fungi; ZR-75-1 cells herbicides; bacteria; fungi; ZR-75-1 cells
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Jabłońska-Trypuć, A.; Wydro, U.; Serra-Majem, L.; Wołejko, E.; Butarewicz, A. The Analysis of Bifenox and Dichlobenil Toxicity in Selected Microorganisms and Human Cancer Cells. Int. J. Environ. Res. Public Health 2019, 16, 4137.

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