Use of Flavored E-Cigarettes and the Type of E-Cigarette Devices Used among Adults and Youth in the US—Results from Wave 3 of the Population Assessment of Tobacco and Health Study (2015–2016)
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design and Population
2.2. Nicotine Use Behavior
2.3. Statistical Analysis
3. Results
3.1. Demographic Characteristics of Past 30-Day Adult and Youth E-Cigarette Users
3.2. Flavor Category Preferences of Past 30-Day Adult and Youth E-Cigarette Users
3.3. Association of Demographic and Nicotine Use Behavior Characteristics with Type of Flavor Category among Past 30-Day Adult and Youth E-Cigarette Users
3.4. Association of Demographic and Nicotine Use Behavior Characteristics with the Number of Flavor Categories Among Past 30-Day Adult and Youth E-Cigarette Users
3.5. Association of Demographic Characteristics and Ever Smoking Status with the Type of Flavor Category Among Past 30-Day Adult E-Cigarette Users
3.6. Association of Type of Flavor Category and Number of Flavor Categories with Past Cigarette Smoking Quit Attempts and Cigarette Smoking Quit Intentions Among Adult Past 30-Day Vapers and Current Smokers
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
- US Food and Drug Administration, H.H.S. Deeming Tobacco Products to Be Subject to the Federal Food, Drug, and Cosmetic Act, as Amended by the Family Smoking Prevention and Tobacco Control Act; Restrictions on the Sale and Distribution of Tobacco Products and Required Warning Statements for Tobacco Products. Final Rule. Available online: https://www.fda.gov/media/97875/download (accessed on 20 August 2019).
- Villanti, A.C.; Johnson, A.L.; Ambrose, B.K.; Cummings, K.M.; Stanton, C.A.; Rose, S.W.; Feirman, S.P.; Tworek, C.; Glasser, A.M.; Pearson, J.L.; et al. Flavored tobacco product use in youth and adults: Findings from the first wave of the PATH Study (2013–2014). Am. J. Prev. Med. 2017. [Google Scholar] [CrossRef] [PubMed]
- Dai, H.; Hao, J. Flavored Electronic Cigarette Use and Smoking Among Youth. Pediatrics 2016, 138, e20162513. [Google Scholar] [CrossRef] [PubMed]
- Fairchild, A.L.; Bayer, R.; Colgrove, J. The renormalization of smoking? E-cigarettes and the tobacco “endgame”. N. Engl. J. Med. 2014, 370, 293–295. [Google Scholar] [CrossRef] [PubMed]
- Soule, E.K.; Lopez, A.A.; Guy, M.C.; Cobb, C.O. Reasons for using flavored liquids among electronic cigarette users: A concept mapping study. Drug Alcohol Depend. 2016, 166, 168–176. [Google Scholar] [CrossRef] [PubMed]
- Coleman, B.N.; Rostron, B.; Johnson, S.E.; Ambrose, B.K.; Pearson, J.; Stanton, C.A.; Wang, B.; Delnevo, C.; Bansal-Travers, M.; Kimmel, H.L.; et al. Electronic cigarette use among US adults in the Population Assessment of Tobacco and Health (PATH) Study, 2013–2014. Tob. Control 2017, 26, e117–e126. [Google Scholar] [CrossRef]
- Cullen, K.A.; Ambrose, B.K.; Gentzke, A.S.; Apelberg, B.J.; Jamal, A.; King, B.A. Notes from the Field: Use of Electronic Cigarettes and Any Tobacco Product Among Middle and High School Students—United States, 2011–2018. Morb. Mortal. Wkly. Rep. (MMWR) 2018, 67, 1276–1277. [Google Scholar] [CrossRef] [PubMed]
- Wang, T.W.; Asman, K.; Gentzke, A.S.; Cullen, K.A.; Holder-Hayes, E.; Reyes-Guzman, C.; Jamal, A.; Neff, L.; King, B.A. Tobacco Product Use Among Adults—United States, 2017. Morb. Mortal. Wkly. Rep. (MMWR) 2018, 67, 1225–1232. [Google Scholar] [CrossRef]
- US Food and Drug Administration. Statement from FDA Commissioner Scott Gottlieb, M.D., on Advancing New Policies Aimed at Preventing Youth Access to, and Appeal of, Flavored Tobacco Products, Including E-Cigarettes and Cigars; US Food and Drug Administration: Silver Spring, MD, USA, 2019.
- Przulj, D.; McRobbie, H.; Hajek, P. The effect of sensorimotor replacement on smoking cessation and craving. Open Addict. J. 2012, 5, 41–50. [Google Scholar] [CrossRef]
- Goldenson, N.I.; Kirkpatrick, M.G.; Barrington-Trimis, J.L.; Pang, R.D.; McBeth, J.F.; Pentz, M.A.; Samet, J.M.; Leventhal, A.M. Effects of sweet flavorings and nicotine on the appeal and sensory properties of e-cigarettes among young adult vapers: Application of a novel methodology. Drug Alcohol Depend. 2016, 168, 176–180. [Google Scholar] [CrossRef]
- Farsalinos, K.E.; Spyrou, A.; Tsimopoulou, K.; Stefopoulos, C.; Romagna, G.; Voudris, V. Nicotine absorption from electronic cigarette use: Comparison between first and new-generation devices. Sci. Rep. 2014, 4, 4133. [Google Scholar] [CrossRef]
- Lopez, A.A.; Hiler, M.M.; Soule, E.K.; Ramoa, C.P.; Karaoghlanian, N.V.; Lipato, T.; Breland, A.B.; Shihadeh, A.L.; Eissenberg, T. Effects of Electronic Cigarette Liquid Nicotine Concentration on Plasma Nicotine and Puff Topography in Tobacco Cigarette Smokers: A Preliminary Report. Nicotine Tob. Res. 2016, 18, 720–723. [Google Scholar] [CrossRef] [PubMed]
- Ramoa, C.P.; Hiler, M.M.; Spindle, T.R.; Lopez, A.A.; Karaoghlanian, N.; Lipato, T.; Breland, A.B.; Shihadeh, A.; Eissenberg, T. Electronic cigarette nicotine delivery can exceed that of combustible cigarettes: A preliminary report. Tob. Control 2016, 25, e6–e9. [Google Scholar] [CrossRef] [PubMed]
- St Helen, G.; Dempsey, D.A.; Havel, C.M.; Jacob, P., 3rd; Benowitz, N.L. Impact of e-liquid flavors on nicotine intake and pharmacology of e-cigarettes. Drug Alcohol Depend. 2017, 178, 391–398. [Google Scholar] [CrossRef] [PubMed]
- Wagener, T.L.; Floyd, E.L.; Stepanov, I.; Driskill, L.M.; Frank, S.G.; Meier, E.; Leavens, E.L.; Tackett, A.P.; Molina, N.; Queimado, L. Have combustible cigarettes met their match? The nicotine delivery profiles and harmful constituent exposures of second-generation and third-generation electronic cigarette users. Tob. Control 2017, 26, e23–e28. [Google Scholar] [CrossRef] [PubMed]
- Walele, T.; Sharma, G.; Savioz, R.; Martin, C.; Williams, J. A randomised, crossover study on an electronic vapour product, a nicotine inhalator and a conventional cigarette. Part B: Safety and subjective effects. Regul. Toxicol. Pharmacol. 2016, 74, 193–199. [Google Scholar] [CrossRef] [PubMed]
- Carpenter, C.M.; Wayne, G.F.; Pauly, J.L.; Koh, H.K.; Connolly, G.N. New cigarette brands with flavors that appeal to youth: Tobacco marketing strategies. Health Aff. (Millwood) 2005, 24, 1601–1610. [Google Scholar] [CrossRef] [PubMed]
- Klein, S.M.; Giovino, G.A.; Barker, D.C.; Tworek, C.; Cummings, K.M.; O’Connor, R.J. Use of flavored cigarettes among older adolescent and adult smokers: United States, 2004–2005. Nicotine Tob. Res. 2008, 10, 1209–1214. [Google Scholar] [CrossRef] [PubMed]
- Kostygina, G.; Glantz, S.A.; Ling, P.M. Tobacco industry use of flavours to recruit new users of little cigars and cigarillos. Tob. Control 2016, 25, 66–74. [Google Scholar] [CrossRef]
- Rabinoff, M.; Caskey, N.; Rissling, A.; Park, C. Pharmacological and chemical effects of cigarette additives. Am. J. Public Health 2007, 97, 1981–1991. [Google Scholar] [CrossRef]
- Squier, C.A.; Mantz, M.J.; Wertz, P.W. Effect of menthol on the penetration of tobacco carcinogens and nicotine across porcine oral mucosa ex vivo. Nicotine Tob. Res. 2010, 12, 763–767. [Google Scholar] [CrossRef]
- Sterling, K.L.; Fryer, C.S.; Nix, M.; Fagan, P. Appeal and Impact of Characterizing Flavors on Young Adult Small Cigar Use. Tob. Regul. Sci. 2015, 1, 42–53. [Google Scholar] [CrossRef] [PubMed]
- US Food and Drug Administration. Statement from FDA Commissioner Scott Gottlieb, M.D., on New Enforcement Actions and a Youth Tobacco Prevention Plan to Stop Youth Use of, and Access to, JUUL and Other E-Cigarettes; US Food and Drug Administration: Silver Spring, MD, USA, 2018.
- Kim, H.; Lim, J.; Buehler, S.S.; Brinkman, M.C.; Johnson, N.M.; Wilson, L.; Cross, K.S.; Clark, P.I. Role of sweet and other flavours in liking and disliking of electronic cigarettes. Tob. Control 2016, 25, ii55–ii61. [Google Scholar] [CrossRef] [PubMed]
- Audrain-McGovern, J.; Strasser, A.A.; Wileyto, E.P. The impact of flavoring on the rewarding and reinforcing value of e-cigarettes with nicotine among young adult smokers. Drug Alcohol Depend. 2016, 166, 263–267. [Google Scholar] [CrossRef] [PubMed]
- Hoffman, A.C.; Salgado, R.V.; Dresler, C.; Faller, R.W.; Bartlett, C. Flavour preferences in youth versus adults: A review. Tob. Control 2016, 25, ii32–ii39. [Google Scholar] [CrossRef] [PubMed]
- Kowitt, S.D.; Meernik, C.; Baker, H.M.; Osman, A.; Huang, L.L.; Goldstein, A.O. Perceptions and Experiences with Flavored Non-Menthol Tobacco Products: A Systematic Review of Qualitative Studies. Int. J. Environ. Res. Public Health 2017, 14, 338. [Google Scholar] [CrossRef] [PubMed]
- Berg, C.J. Preferred flavors and reasons for e-cigarette use and discontinued use among never, current, and former smokers. Int. J. Public Health 2016, 61, 225–236. [Google Scholar] [CrossRef] [PubMed]
- Dawkins, L.; Turner, J.; Roberts, A.; Soar, K. ‘Vaping’ profiles and preferences: An online survey of electronic cigarette users. Addiction 2013, 108, 1115–1125. [Google Scholar] [CrossRef] [PubMed]
- Morean, M.E.; Butler, E.R.; Bold, K.W.; Kong, G.; Camenga, D.R.; Cavallo, D.A.; Simon, P.; O’Malley, S.S.; Krishnan-Sarin, S. Preferring more e-cigarette flavors is associated with e-cigarette use frequency among adolescents but not adults. PLoS ONE 2018, 13, e0189015. [Google Scholar] [CrossRef]
- Schneller, L.M.; Bansal-Travers, M.; Goniewicz, M.L.; McIntosh, S.; Ossip, D.; O’Connor, R.J. Use of flavored electronic cigarette refill liquids among adults and youth in the US-Results from Wave 2 of the Population Assessment of Tobacco and Health Study (2014–2015). PLoS ONE 2018, 13, e0202744. [Google Scholar] [CrossRef]
- Westat. PATH Study Public Use Files User Guide; ICPSR: Rockville, MD, USA, 2017; Volume 36498. [Google Scholar]
- Soneji, S.S.; Knutzen, K.E.; Villanti, A.C. Use of Flavored E-Cigarettes Among Adolescents, Young Adults, and Older Adults: Findings from the Population Assessment for Tobacco and Health Study. Public Health Rep. 2019, 134, 282–292. [Google Scholar] [CrossRef]
- Morean, M.E.; Kong, G.; Cavallo, D.A.; Camenga, D.R.; Krishnan-Sarin, S. Nicotine concentration of e-cigarettes used by adolescents. Drug Alcohol Depend. 2016, 167, 224–227. [Google Scholar] [CrossRef] [PubMed]
- Russell, C.; McKeganey, N.; Dickson, T.; Nides, M. Changing patterns of first e-cigarette flavor used and current flavors used by 20,836 adult frequent e-cigarette users in the USA. Harm Reduct. J. 2018, 15, 33. [Google Scholar] [CrossRef] [PubMed]
- Harrell, M.B.; Weaver, S.R.; Loukas, A.; Creamer, M.; Marti, C.N.; Jackson, C.D.; Heath, J.W.; Nayak, P.; Perry, C.L.; Pechacek, T.F.; et al. Flavored e-cigarette use: Characterizing youth, young adult, and adult users. Prev. Med. Rep. 2017, 5, 33–40. [Google Scholar] [CrossRef] [PubMed]

| Characteristics Assessed at W3 | Adult Past 30-day ENDS User | Youth Past 30-day ENDS User | p-Value |
|---|---|---|---|
| N = 2784 | N = 433 | ||
| Gender, N (%) | 0.6465 | ||
| Male | 1484 (55.2) | 230 (53.9) | |
| Female | 1299 (44.9) | 202 (46.1) | |
| Race/Ethnicity, N (%) | 0.3568 | ||
| Non-Hispanic White | 2095 (79.7) | 313 (78.5) | |
| Non-Hispanic Black | 303 (10.5) | 41 (9.5) | |
| Other groups | 319 (9.8) | 67 (12.0) | |
| Number of Flavor Categories, N (%) | <0.0001 | ||
| 1 Flavor Category | 1809 (66.6) | 226 (51.6) | |
| 2+ Flavor Categories | 944 (32.1) | 194 (45.5) | |
| Don’t Know | 31 (1.3) | 13 (2.9) | |
| Flavor Category, N (%) | <0.0001 | ||
| Tobacco alone | 383 (16.5) | 13 (2.7) | |
| All other flavors and flavor combinations | 2370 (83.5) | 407 (97.3) | |
| ENDs Device, N (%) | <0.0001 | ||
| Open | 2128 (76.7) | 325 (85.9) | |
| Closed | 632 (23.3) | 54 (14.1) | |
| Dual Use of Cigarettes, N (%) | <0.0001 | ||
| Exclusive Vaper | 796 (37.6) | 283 (66.3) | |
| Vaper and Smoker | 1403 (62.4) | 145 (33.7) | |
| Smoking Frequency, N (%) | <0.0001 | ||
| Never | 197 (6.9) | 167 (38.3) | |
| Former | 599 (30.7) | 116 (28.0) | |
| Current | 1403 (62.4) | 145 (33.7) |
| Most Common Flavors | |||
|---|---|---|---|
| Adult Past 30-day ENDS User N = 1809 | Youth Past 30-day ENDS User N = 226 | ||
| % (LB, UB) | % (LB, UB) | ||
| Fruit | 30.8 (28.1, 33.6) | Fruit | 52.8 (45.4, 60.1) |
| Tobacco | 24.5 (21.6, 27.6) | Candy/desserts/other sweets | 24.4 (19.9, 29.7) |
| Candy/desserts/other sweets | 18.2 (15.7, 21.1) | Menthol/Mint | 10.8 (7.0, 16.2) |
| Menthol/Mint | 17.9 (15.9, 20.1) | Tobacco | 5.1 (3.0, 8.4) |
| Other flavor | 3.1 (2.2, 4.3) | Chocolate | 3.0 (1.1, 7.8) |
| Non-Alcoholic Beverage | 2.5 (1.9, 3.5) | Alcoholic Beverage | 1.1 (0.2, 5.3) |
| Alcoholic Beverage | 1.5 (0.9, 2.5) | Non-alcoholic Beverage | 1.0 (0.3, 3.2) |
| Chocolate | 0.9 (0.6, 1.6) | Other flavor | 1.0 (0.3, 3.2) |
| Clove/Spice | 0.6 (0.3, 1.1) | Clove/Spice | 0.8 (0.2, 3.1) |
| Most Common Flavor Combinations | |||
| Adult Past 30-day ENDS User N = 944 | Youth Past 30-day ENDS User N = 194 | ||
| % (LB, UB) | % (LB, UB) | ||
| Candy/desserts/other sweets and some other flavor | 33.4 (29.9, 37.1) | Fruit and Candy/desserts/other sweets | 35.6 (29.1, 42.6) |
| Menthol/Mint and Fruit | 7.6 (5.6, 10.1) | Fruit, Non-Alcoholic Beverage and Candy/desserts/other sweets | 8.1 (4.8, 13.3) |
| Menthol/Mint, Fruit, and Candy/desserts/other sweets | 6.7 (4.9, 9.1) | Fruit, Chocolate, and Candy/desserts/other sweets | 5.6 (3.3, 9.3) |
| Tobacco and Menthol/Mint | 4.0 (2.5, 6.1) | Menthol/Mint, Fruit and Candy/desserts/other sweets | 3.6 (1.8, 7.1) |
| Fruit, Non-Alcoholic Beverage, and Candy/desserts/other sweets | 3.7 (2.8, 5.0) | Fruit, Alcoholic Beverage, and Candy/desserts/other sweets | 3.6 (1.5, 8.2) |
| Fruit, Chocolate, and Candy/desserts/other sweets | 3.4 (2.2, 5.4) | Menthol/Mint and Fruit | 3.6 (1.6, 7.8) |
| Tobacco and Fruit | 3.2 (2.1, 4.9) | Menthol/Mint, Fruit, Non-Alcoholic Beverage, and Candy/desserts/other sweets | 2.5 (0.9, 6.8) |
| Menthol/Mint and Candy/desserts/other sweets | 2.6 (1.7, 4.2) | Tobacco, Fruit, and Candy/desserts/other sweets | 2.3 (0.9, 5.6) |
| Tobacco, Fruit, and Candy/desserts/other sweets | 2.4 (1.4, 4.1) | Fruit and Chocolate | 2.0 (0.6, 6.5) |
| Tobacco and Candy/desserts/other sweets | 1.9 (1.1, 3.2) | Tobacco and Menthol/Mint | 2.0 (0.6, 6.4) |
| Tobacco Flavor Alone | All Other Flavors and Flavor Combinations | |||
|---|---|---|---|---|
| N = 396 | N = 2777 | |||
| N (%) | N (%) | Crude | Adjusted a | |
| Age Group | ||||
| Adult | 383 (98.8) | 2370 (91.9) | Ref | Ref |
| Youth | 13 (1.2) | 407 (8.2) | 7.14 (4.03, 12.7) | 21.08 (5.92, 75.12) |
| Gender | ||||
| Male | 214 (58.6) | 1479 (54.6) | Ref | Ref |
| Female | 182 (41.4) | 1296 (45.4) | 1.17 (0.90, 1.54) | 1.40 (1.07, 1.83) |
| Race/Ethnicity | ||||
| Non-Hispanic White | 316 (82.5) | 2059 (79.0) | Ref | Ref |
| Non-Hispanic Black | 40 (10.9) | 302 (10.5) | 1.01 (0.59, 1.73) | 1.40 (0.71, 2.76) |
| Other | 36 (6.6) | 342 (10.5) | 1.66 (1.09, 2.53) | 2.08 (1.33, 3.24) |
| ENDS Device | ||||
| Closed | 202 (51.1) | 471 (17.3) | Ref | Ref |
| Open | 184 (48.9) | 2247 (82.7) | 5.00 (3.84, 6.51) | 5.42 (4.07, 7.22) |
| Dual Use of Cigarettes | ||||
| Exclusive Vaper | 92 (27.6) | 968 (42.4) | Ref | Ref |
| Vaper and Smoker | 257 (72.4) | 1277 (57.6) | 0.52 (0.38, 0.70) | 0.67 (0.48, 0.93) |
| Tobacco Flavor Alone | All Other Flavors and Flavor Combinations | |||
|---|---|---|---|---|
| N = 383 | N = 2187 | |||
| N (%) | N (%) | Crude | Adjusted a | |
| Age | ||||
| 18–24 years | 45 (6.3) | 1086 (32.9) | Ref | Ref |
| 25–34 years | 63 (18.7) | 588 (28.5) | 0.29 (0.18, 0.47) | 0.37 (0.19, 0.71) |
| 35–54 years | 167 (44.2) | 513 (27.0) | 0.12 (0.08, 0.17) | 0.13 (0.08, 0.23) |
| 55 years and older | 108 (30.8) | 183 (11.53) | 0.07 (0.05, 0.11) | 0.08 (0.05, 0.14) |
| Gender | ||||
| Male | 207 (58.5) | 1261 (54.7) | Ref | Ref |
| Female | 176 (41.5) | 1108 (45.3) | 1.17 (0.89, 1.54) | 1.75 (1.29, 2.36) |
| Race/Ethnicity | ||||
| Non-Hispanic White | 308 (82.8) | 1764 (79.0) | Ref | Ref |
| Non-Hispanic Black | 37 (10.6) | 265 (10.6) | 1.04 (0.59, 1.83) | 2.65 (1.37, 5.12) |
| Other | 35 (6.6) | 278 (10.4) | 1.64 (1.06, 2.51) | 1.34 (0.77, 2.33) |
| ENDS Device | ||||
| Closed | 199 (51.0) | 423 (17.6) | Ref | Ref |
| Open | 182 (49.0) | 1931 (82.4) | 4.87 (3.70, 6.41) | 5.31 (3.84, 7.34) |
| Ever Smoker Status | ||||
| Current | 252 (73.1) | 1138 (65.5) | Ref | Ref |
| Former | 83 (26.9) | 513 (34.5) | 1.43 (1.04, 1.96) | 1.46 (1.00, 2.12) |
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Share and Cite
Schneller, L.M.; Bansal-Travers, M.; Goniewicz, M.L.; McIntosh, S.; Ossip, D.; O’Connor, R.J. Use of Flavored E-Cigarettes and the Type of E-Cigarette Devices Used among Adults and Youth in the US—Results from Wave 3 of the Population Assessment of Tobacco and Health Study (2015–2016). Int. J. Environ. Res. Public Health 2019, 16, 2991. https://doi.org/10.3390/ijerph16162991
Schneller LM, Bansal-Travers M, Goniewicz ML, McIntosh S, Ossip D, O’Connor RJ. Use of Flavored E-Cigarettes and the Type of E-Cigarette Devices Used among Adults and Youth in the US—Results from Wave 3 of the Population Assessment of Tobacco and Health Study (2015–2016). International Journal of Environmental Research and Public Health. 2019; 16(16):2991. https://doi.org/10.3390/ijerph16162991
Chicago/Turabian StyleSchneller, Liane M., Maansi Bansal-Travers, Maciej L. Goniewicz, Scott McIntosh, Deborah Ossip, and Richard J. O’Connor. 2019. "Use of Flavored E-Cigarettes and the Type of E-Cigarette Devices Used among Adults and Youth in the US—Results from Wave 3 of the Population Assessment of Tobacco and Health Study (2015–2016)" International Journal of Environmental Research and Public Health 16, no. 16: 2991. https://doi.org/10.3390/ijerph16162991
APA StyleSchneller, L. M., Bansal-Travers, M., Goniewicz, M. L., McIntosh, S., Ossip, D., & O’Connor, R. J. (2019). Use of Flavored E-Cigarettes and the Type of E-Cigarette Devices Used among Adults and Youth in the US—Results from Wave 3 of the Population Assessment of Tobacco and Health Study (2015–2016). International Journal of Environmental Research and Public Health, 16(16), 2991. https://doi.org/10.3390/ijerph16162991

