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Article

Indirect Costs of Rheumatoid Arthritis Depending on Type of Treatment—A Systematic Literature Review

1
Department of Rheumatology, J. Dietl Specialist Hospital, Skarbowa 1 St, 31-121 Cracow, Poland
2
HTA Consulting, Starowislna 17/3 St, 31-038 Cracow, Poland
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(16), 2966; https://doi.org/10.3390/ijerph16162966
Received: 21 July 2019 / Revised: 12 August 2019 / Accepted: 15 August 2019 / Published: 17 August 2019
(This article belongs to the Special Issue Return to Work and Occupational Health Services)
The economic burden of rheumatoid arthritis (RA) on society is high. Disease-modifying antirheumatic drugs (DMARDs) are the cornerstone of therapy. Biological DMARDs are reported to prevent disability and improve quality of life, thus reducing indirect RA costs. We systematically reviewed studies on the relationship between RA and indirect costs comparing biological treatment with standard care. Studies, economic analyses, and systematic reviews published until October 2018 through a MEDLINE search were included. A total of 153 non-duplicate citations were identified, 92 (60%) were excluded as they did not meet pre-defined inclusion criteria. Sixty-one articles were included, 17 of them (28%) were reviews. After full-text review, 28 articles were included, 11 of them were reviews. Costs associated with productivity loss are substantial; in several cases, they may represent over 50% of the total. The most common method of estimation is the Human Capital method. However, certain heterogeneity is observed in the method of estimating, as well as in the resultant figures. Data from included trials indicate that biological therapy is associated with improved labor force participation despite an illness, in which the natural course of disease is defined by progressive work impairment. Use of biological DMARDs may lead to significant indirect cost benefits to society. View Full-Text
Keywords: rheumatoid arthritis; productivity loss; workplace; absenteeism; cost of illness; economic burden; indirect cost; presenteeism; sick leave; systematic review rheumatoid arthritis; productivity loss; workplace; absenteeism; cost of illness; economic burden; indirect cost; presenteeism; sick leave; systematic review
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MDPI and ACS Style

Batko, B.; Rolska-Wójcik, P.; Władysiuk, M. Indirect Costs of Rheumatoid Arthritis Depending on Type of Treatment—A Systematic Literature Review. Int. J. Environ. Res. Public Health 2019, 16, 2966. https://doi.org/10.3390/ijerph16162966

AMA Style

Batko B, Rolska-Wójcik P, Władysiuk M. Indirect Costs of Rheumatoid Arthritis Depending on Type of Treatment—A Systematic Literature Review. International Journal of Environmental Research and Public Health. 2019; 16(16):2966. https://doi.org/10.3390/ijerph16162966

Chicago/Turabian Style

Batko, Bogdan, Paulina Rolska-Wójcik, and Magdalena Władysiuk. 2019. "Indirect Costs of Rheumatoid Arthritis Depending on Type of Treatment—A Systematic Literature Review" International Journal of Environmental Research and Public Health 16, no. 16: 2966. https://doi.org/10.3390/ijerph16162966

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