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Increased Incidence of Glaucoma in Sensorineural Hearing Loss: A Population-Based Cohort Study

1,2,3,†, 4,†, 1,2,3, 5,6, 7, 1,7, 8,9,10,* and 11,12,*
1
Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
2
Departments of Ophthalmology, Sijhih Cathay General Hospital, New Taipei City 221, Taiwan
3
Department of Ophthalmology, Cathay General Hospital, Taipei 106, Taiwan
4
Department of Otolaryngology–Head and Neck Surgery, Tri-Service General Hospital, Taipei 114, Taiwan
5
Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung 204, Taiwan
6
Department of Chinese Medicine, Chang Gung University, Taoyuan City 333, Taiwan
7
Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
8
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou 333, Taiwan
9
Department of Medicine, Chang Gung University College of Medicine, Taoyuan 333, Taiwan
10
Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou 333, Taiwan
11
Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
12
Department of Optometry, College of Medicine and Life Science, Chung Hwa University of Medical Technology, Tainan 717, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to the research.
Int. J. Environ. Res. Public Health 2019, 16(16), 2907; https://doi.org/10.3390/ijerph16162907
Received: 2 August 2019 / Revised: 11 August 2019 / Accepted: 12 August 2019 / Published: 14 August 2019
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PDF [997 KB, uploaded 14 August 2019]
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Abstract

The purpose of the current study was to evaluate the incidence of glaucoma in patients diagnosed with sensorineural hearing loss (SNHL) via the application of the National Health Insurance Research Database in Taiwan. A retrospective cohort study was conducted. Patients with a diagnosis of SNHL were enrolled in the study group after an exclusion procedure and a propensity score matched group without SNHL was served as the control group with a 1:2 ratio. The main outcome was regarded as the emergence of glaucoma diagnostic codes. Cox proportional hazard regression was applied to analyze the incidence and adjusted hazard ratio (aHR) of glaucoma in the multivariate model. A total of 15,686 patients diagnosed with SNHL were enrolled in the study group while another 31,372 non-SNHL individuals served as the control group. There were 444 glaucoma events in the study group and 647 glaucoma events in those non-SNHL individuals after the follow-up interval of 16 years. The study group demonstrated a significantly higher aHR compared to the control group after adjusting for multiple possible risk factors. In the subgroup analysis, both the normal tension glaucoma and angle closure glaucoma subgroups revealed a higher aHR in the study group. In conclusion, the patients with SNHL demonstrated a higher incidence of developing glaucoma. Moreover, the incidence was more prominent for patients diagnosed with normal tension glaucoma and angle closure glaucoma. View Full-Text
Keywords: glaucoma; sensorineural hearing loss; epidemiology; degeneration; neuropathy glaucoma; sensorineural hearing loss; epidemiology; degeneration; neuropathy
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MDPI and ACS Style

Chien, H.-W.; Wu, P.-H.; Wang, K.; Sun, C.-C.; Huang, J.-Y.; Yang, S.-F.; Chen, H.-C.; Lee, C.-Y. Increased Incidence of Glaucoma in Sensorineural Hearing Loss: A Population-Based Cohort Study. Int. J. Environ. Res. Public Health 2019, 16, 2907.

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