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Evaluation of HBV-Like Circulation in Wild and Farm Animals from Brazil and Uruguay

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Laboratório de Desenvolvimento Tecnológico em Virologia, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, Rio de Janeiro, RJ 21040-900, Brazil
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Laboratório de Hepatites Virais, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, Rio de Janeiro, RJ 21040-900, Brazil
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Laboratório de Virologia Molecular, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, Rio de Janeiro, RJ 21040-900, Brazil
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Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz, Rio de Janeiro, RJ 21040-900, Brazil
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Laboratório de Viroses Veterinárias, Departamento de Microbiologia Veterinária e Imunologia, Universidade Federal Rural do Rio de Janeiro (UFRRJ), Seropédica, RJ 23897-000, Brazil
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Sección Virología, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay
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Departamento de Medicina e Cirurgia, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro (UFRRJ), Seropédica, RJ 23897-000, Brazil
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Fiocruz Mata Atlântica, Fundação Oswaldo Cruz, Rio de Janeiro, RJ 22713-560, Brazil
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Centro de Ciências Aplicadas e Educação, Campus IV Litoral Norte, Universidade Federal da Paraíba, Rio Tinto, PB 58297-000, Brazil
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Programa de Conservação Mamíferos do Cerrado (PCMC), Cumari, GO 74690-900, Brazil
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Unidade Acadêmica Especial de Biotecnologia, Universidade Federal de Goiás, Goiânia, GO 74690-900, Brazil
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Laboratório de Biologia Parasitária, Universidade Católica Dom Bosco, Campo Grande, MS 79117-010, Brazil
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Embrapa Pantanal, CP 109, Corumbá, MS 79320-900, Brazil
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Faculdade de Medicina Veterinária e Zootecnia, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS 79070-900, Brazil
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Embrapa Tabuleiros Costeiros, Aracaju, SE 49040-490, Brazil
*
Authors to whom correspondence should be addressed.
These authors contributed equally as last authors.
Int. J. Environ. Res. Public Health 2019, 16(15), 2679; https://doi.org/10.3390/ijerph16152679
Received: 26 April 2019 / Revised: 2 July 2019 / Accepted: 8 July 2019 / Published: 26 July 2019
The origin of the hepatitis B virus is a subject of wide deliberation among researchers. As a result, increasing academic interest has focused on the spread of the virus in different animal species. However, the sources of viral infection for many of these animals are unknown since transmission may occur from animal to animal, human to human, animal to human, and human to animal. The aim of this study was to evaluate hepadnavirus circulation in wild and farm animals (including animals raised under wild or free conditions) from different sites in Brazil and Uruguay using serological and molecular tools. A total of 487 domestic wild and farm animals were screened for hepatitis B virus (HBV) serological markers and tested via quantitative and qualitative polymerase chain reaction (PCR) to detect viral DNA. We report evidence of HBsAg (surface antigen of HBV) and total anti-HBc (HBV core antigen) markers as well as low-copy hepadnavirus DNA among domestic and wild animals. According to our results, which were confirmed by partial genome sequencing, as the proximity between humans and animals increases, the potential for pathogen dispersal also increases. A wider knowledge and understanding of reverse zoonoses should be sought for an effective One Health response. View Full-Text
Keywords: hepadnavirus; animal infectious diseases; disease impact; reverse zoonoses; real-time PCR hepadnavirus; animal infectious diseases; disease impact; reverse zoonoses; real-time PCR
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Vieira, Y.R.; Portilho, M.M.; Oliveira, F.F.; Guterres, A.; dos Santos, D.R.L.; Villar, L.M.; Mirazo, S.; Arbiza, J.; Dimache, L.A.; Almeida, F.Q.; Brandão, M.L.; Cordeiro, J.L.P.; Rocha, F.L.; Azevedo, F.C.; Lemos, F.G.; Campos, J.B.V.; Macedo, G.C.; Herrera, H.M.; Péres, I.A.S.; Zimmermann, N.P.; Piovezan, U.; Pellegrin, A.O.; de Paula, V.S.; Pinto, M.A. Evaluation of HBV-Like Circulation in Wild and Farm Animals from Brazil and Uruguay. Int. J. Environ. Res. Public Health 2019, 16, 2679.

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