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Int. J. Environ. Res. Public Health 2019, 16(1), 120; https://doi.org/10.3390/ijerph16010120

The Relationship between Nkx2.1 and DNA Oxidative Damage Repair in Nickel Smelting Workers: Jinchang Cohort Study

1
Evidence-Based Medicine Centre, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
2
School of Public Health, Department of Epidemiology and Statistics, Lanzhou University, Lanzhou 730000, China
3
Centre of Medical Laboratory, School of Basic Medical Science, Lanzhou University, Lanzhou 730000, China
*
Author to whom correspondence should be addressed.
Received: 17 November 2018 / Revised: 28 December 2018 / Accepted: 30 December 2018 / Published: 4 January 2019
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Abstract

Background: Occupational nickel exposure can cause DNA oxidative damage and influence DNA repair. However, the underlying mechanism of nickel-induced high-risk of lung cancer has not been fully understood. Our study aims to evaluate whether the nickel-induced oxidative damage and DNA repair were correlated with the alterations in Smad2 phosphorylation status and Nkx2.1 expression levels, which has been considered as the lung cancer initiation gene. Methods: 140 nickel smelters and 140 age-matched administrative officers were randomly stratified by service length from Jinchang Cohort. Canonical regression, χ2 test, Spearman correlation etc. were used to evaluate the association among service length, MDA, 8-OHdG, hOGG1, PARP, pSmad2, and Nkx2.1. Results: The concentrations of MDA, PARP, pSmad2, and Nkx2.1 significantly increased. Nkx2.1 (rs = 0.312, p < 0.001) and Smad2 phosphorylation levels (rs = 0.232, p = 0.006) were positively correlated with the employment length in nickel smelters, which was not observed in the administrative officer group. Also, elevation of Nkx2.1 expression was positively correlated with service length, 8-OHdG, PARP, hOGG1 and pSmad2 levels in nickel smelters. Conclusions: Occupational nickel exposure could increase the expression of Nkx2.1 and pSmad2, which correlated with the nickel-induced oxidative damage and DNA repair change. View Full-Text
Keywords: nickel smelters; Nkx2.1; pSmad2; oxidative stress; DNA repair nickel smelters; Nkx2.1; pSmad2; oxidative stress; DNA repair
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Cheng, Z.; Cheng, N.; Shi, D.; Ren, X.; Gan, T.; Bai, Y.; Yang, K. The Relationship between Nkx2.1 and DNA Oxidative Damage Repair in Nickel Smelting Workers: Jinchang Cohort Study. Int. J. Environ. Res. Public Health 2019, 16, 120.

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