Mortality Due to Cystic Fibrosis over a 36-Year Period in Spain: Time Trends and Geographic Variations
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Research Ethics
References
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Both Sexes | Males | Females | ||||
---|---|---|---|---|---|---|
Year | Age Adjusted Mortality Rate | 95% CI | Age Adjusted Mortality Rate | 95% CI | Age Adjusted Mortality Rate | 95% CI |
1981 | 0.090 | (0.064–0.126) | 0.089 | (0.054–0.154) | 0.092 | (0.055–0.147) |
1982 | 0.083 | (0.057–0.117) | 0.076 | (0.043–0.136) | 0.089 | (0.053–0.145) |
1983 | 0.093 | (0.066–0.130) | 0.105 | (0.063–0.174) | 0.084 | (0.049–0.138) |
1984 | 0.086 | (0.058–0.123) | 0.087 | (0.049–0.150) | 0.085 | (0.047–0.143) |
1985 | 0.095 | (0.066–0.132) | 0.111 | (0.069–0.177) | 0.076 | (0.042–0.129) |
1986 | 0.078 | (0.051–0.114) | 0.098 | (0.057–0.162) | 0.056 | (0.027–0.107) |
1987 | 0.063 | (0.039–0.096) | 0.042 | (0.018–0.091) | 0.084 | (0.047–0.143) |
1988 | 0.056 | (0.034–0.089) | 0.060 | (0.028–0.115) | 0.052 | (0.024–0.101) |
1989 | 0.085 | (0.057–0.123) | 0.113 | (0.069–0.178) | 0.057 | (0.027–0.109) |
1990 | 0.058 | (0.036–0.090) | 0.037 | (0.016–0.079) | 0.079 | (0.042–0.138) |
1991 | 0.052 | (0.030–0.085) | 0.049 | (0.022–0.098) | 0.056 | (0.025–0.111) |
1992 | 0.062 | (0.039–0.096) | 0.075 | (0.040–0.132) | 0.049 | (0.022–0.099) |
1993 | 0.075 | (0.047–0.113) | 0.079 | (0.041–0.139) | 0.071 | (0.034–0.131) |
1994 | 0.058 | (0.035–0.093) | 0.040 | (0.017–0.086) | 0.077 | (0.039–0.139) |
1995 | 0.060 | (0.038–0.094) | 0.048 | (0.021–0.098) | 0.075 | (0.040–0.132) |
1996 | 0.089 | (0.061–0.127) | 0.108 | (0.066–0.171) | 0.067 | (0.035–0.123) |
1997 | 0.076 | (0.050–0.114) | 0.083 | (0.045–0.144) | 0.069 | (0.036–0.126) |
1998 | 0.057 | (0.034–0.091) | 0.044 | (0.018–0.096) | 0.069 | (0.035–0.128) |
1999 | 0.065 | (0.042–0.099) | 0.056 | (0.028–0.107) | 0.074 | (0.040–0.133) |
2000 | 0.042 | (0.025–0.070) | 0.045 | (0.022–0.091) | 0.040 | (0.018–0.088) |
2001 | 0.050 | (0.030–0.082) | 0.049 | (0.022–0.102) | 0.053 | (0.026–0.105) |
2002 | 0.038 | (0.022–0.065) | 0.033 | (0.013–0.077) | 0.041 | (0.019–0.088) |
2003 | 0.070 | (0.046–0.105) | 0.079 | (0.043–0.137) | 0.063 | (0.033–0.115) |
2004 | 0.090 | (0.062–0.128) | 0.077 | (0.043–0.132) | 0.104 | (0.062–0.168) |
2005 | 0.053 | (0.033–0.082) | 0.054 | (0.027–0.100) | 0.052 | (0.026–0.098) |
2006 | 0.030 | (0.016–0.052) | 0.029 | (0.011–0.067) | 0.029 | (0.012–0.067) |
2007 | 0.064 | (0.041–0.096) | 0.047 | (0.023–0.090) | 0.087 | (0.049–0.146) |
2008 | 0.065 | (0.043–0.096) | 0.074 | (0.043–0.123) | 0.058 | (0.029–0.107) |
2009 | 0.076 | (0.052–0.109) | 0.068 | (0.037–0.117) | 0.084 | (0.049–0.138) |
2010 | 0.072 | (0.048–0.104) | 0.088 | (0.052–0.142) | 0.053 | (0.027–0.098) |
2011 | 0.055 | (0.035–0.082) | 0.044 | (0.022–0.082) | 0.067 | (0.037–0.115) |
2012 | 0.061 | (0.041–0.090) | 0.056 | (0.030–0.099) | 0.066 | (0.037–0.113) |
2013 | 0.079 | (0.054–0.113) | 0.057 | (0.031–0.101) | 0.106 | (0.064–0.167) |
2014 | 0.063 | (0.040–0.094) | 0.072 | (0.040–0.124) | 0.053 | (0.026–0.100) |
2015 | 0.057 | (0.038–0.085) | 0.050 | (0.027–0.090) | 0.066 | (0.037–0.114) |
2016 | 0.049 | (0.030–0.078) | 0.054 | (0.027–0.100) | 0.044 | (0.020–0.090) |
District | Province | Location | Both Sexes | Males | Females |
---|---|---|---|---|---|
Very low risk | |||||
Área Metropolitana de Madrid | Madrid | C | 0.658 (0.453–0.924) | - | 0.598 (0.341–0.970) |
High risk | |||||
Brozas | Cáceres | W | 15.462 (1.736–55.825) | - | 30.304 (3.403–109.413) |
Alto Maestrazgo | Castellón | E | 12.091 (1.358–43.654) | - | - |
Logrosán | Cáceres | W | 10.474 (1.176–37.817) | - | - |
Guadix | Granada | S | 5.468 (1.099–15.978) | - | - |
Campiña Alta | Córdoba | S | 3.168 (1.269–6.527) | 4.652 (1.499–10.856) | - |
Campo de Gibraltar | Cádiz | S | 2.892 (1.245–5.698) | 3.783 (1.219–8.829) | - |
Norte de Tenerife | SC de Tenerife | SW * | 2.473 (1.184–4.549) | - | 2.849 (1.040–6.200) |
Gran Canaria | Las Palmas | SW * | 2.331 (1.423–3.600) | 2.664 (1.328–4.767) | - |
La Vega | Sevilla | SW | 2.201 (1.004–4.178) | 2.169 (1.119–3.788) | - |
La Campiña | Sevilla | SW | 1.934 (1.225–2.902) | - | 2.816 (1.028–6.129) |
Guadalhorce | Málaga | S | 1.798 (1.126–2.722) | - | - |
Campo de Cartagena | Murcia | SE | - | 3.395 (1.240–7.390) | - |
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Villaverde-Hueso, A.; Sánchez-Díaz, G.; Molina-Cabrero, F.J.; Gallego, E.; Posada de la Paz, M.; Alonso-Ferreira, V. Mortality Due to Cystic Fibrosis over a 36-Year Period in Spain: Time Trends and Geographic Variations. Int. J. Environ. Res. Public Health 2019, 16, 119. https://doi.org/10.3390/ijerph16010119
Villaverde-Hueso A, Sánchez-Díaz G, Molina-Cabrero FJ, Gallego E, Posada de la Paz M, Alonso-Ferreira V. Mortality Due to Cystic Fibrosis over a 36-Year Period in Spain: Time Trends and Geographic Variations. International Journal of Environmental Research and Public Health. 2019; 16(1):119. https://doi.org/10.3390/ijerph16010119
Chicago/Turabian StyleVillaverde-Hueso, Ana, Germán Sánchez-Díaz, Francisco J. Molina-Cabrero, Elisa Gallego, Manuel Posada de la Paz, and Verónica Alonso-Ferreira. 2019. "Mortality Due to Cystic Fibrosis over a 36-Year Period in Spain: Time Trends and Geographic Variations" International Journal of Environmental Research and Public Health 16, no. 1: 119. https://doi.org/10.3390/ijerph16010119
APA StyleVillaverde-Hueso, A., Sánchez-Díaz, G., Molina-Cabrero, F. J., Gallego, E., Posada de la Paz, M., & Alonso-Ferreira, V. (2019). Mortality Due to Cystic Fibrosis over a 36-Year Period in Spain: Time Trends and Geographic Variations. International Journal of Environmental Research and Public Health, 16(1), 119. https://doi.org/10.3390/ijerph16010119