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Open AccessArticle

Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population

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Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung 40402, Taiwan
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Division of Nephrology and Kidney Institute, China Medical University Hospital, Taichung 40447, Taiwan
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Department of Chest Medicine, China Medical University Hospital, Taichung 40447, Taiwan
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Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan
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College of Medicine, China Medical University, Taichung 40447, Taiwan
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Department of Family Medicine, China Medical University Hospital, Taichung 40447, Taiwan
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Department of Ophthalmology, China Medical University Hospital, Taichung 40447, Taiwan
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Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung 40447, Taiwan
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Department of Bioinformatics and Medical Engineering, Asia University, Taichung 40447, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(5), 902; https://doi.org/10.3390/ijerph15050902
Received: 15 March 2018 / Revised: 30 April 2018 / Accepted: 30 April 2018 / Published: 3 May 2018
Direct evidence of whether thyroid cancer patients have a higher risk of age-related macular degeneration (AMD) has yet to be investigated. Patients older than 50 years-old and newly diagnosed with thyroid cancer between 2000 and 2008 were identified from the national health insurance research database (NHIRD). We applied time-varying Cox proportional hazard models to assess the association between thyroid cancer and AMD. The multivariable models included conventional cardiovascular risk factors, myopia, vitreous floaters, hypothyroidism, hyperthyroidism, and treatment modality of thyroid cancer. The analysis process was stratified by age, gender, and comorbidity. In this study, 5253 patients were included in a thyroid cancer cohort (men 24.5%; median age 59.1 years (53.7–67.4 years), and 21,012 matched controls were included in a non-thyroid cancer cohort. The AMD incidence was 40.7 per 10,000 person/year in the thyroid cancer cohort. The thyroid cancer cohort had a higher risk (adjusted hazard ratio (aHR) = 1.38, 95% confidence interval, CI = 1.09–1.75) of AMD than the non-thyroid cohort. Thyroid cancer patients had a higher risk of AMD, especially the male patients (aHR = 1.92, 95% CI = 1.38–3.14) and the patients with comorbidities (aHR = 1.38, 95% CI = 1.09–1.74). In conclusion, thyroid cancer patients older than 50 years-old have increased risk of AMD. View Full-Text
Keywords: thyroid cancer; age-related macular degeneration; national health insurance research database thyroid cancer; age-related macular degeneration; national health insurance research database
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Lin, S.-Y.; Hsu, W.-H.; Lin, C.-L.; Lin, C.-C.; Lin, J.-M.; Chang, Y.-L.; Hsu, C.-Y.; Kao, C.-H. Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population. Int. J. Environ. Res. Public Health 2018, 15, 902.

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