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PALTEM: What Parameters Should Be Collected in Disaster Settings to Assess the Long-Term Outcomes of Famine?

1
Centre for Research on the Epidemiology of Disasters, Université Catholique de Louvain, Brussels 1200, Belgium
2
Institute of Health and Society, Université Catholique de Louvain, Brussels 1200, Belgium
3
Department of Public Health and Primary Care, Katholieke Universiteit Leuven, Leuven 3000, Belgium
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(5), 857; https://doi.org/10.3390/ijerph15050857
Received: 8 March 2018 / Revised: 14 April 2018 / Accepted: 21 April 2018 / Published: 25 April 2018
(This article belongs to the Special Issue Dietary Exposures)
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Abstract

Evidence suggests that nutritional status during fetal development and early life leaves an imprint on the genome, which leads to health outcomes not only on a person as an adult but also on his offspring. The purpose of this study is to bring forth an overview of the relevant parameters that need to be collected to assess the long-term and transgenerational health outcomes of famine. A literature search was conducted for the most pertinent articles on the epigenetic effects of famine. The results were compiled, synthesized and discussed with an expert in genetics for critical input and validation. Prenatal and early life exposure to famine was associated with metabolic, cardiovascular, respiratory, reproductive, neuropsychiatric and oncologic diseases. We propose a set of parameters to be collected in disaster settings to assess the long-term outcomes of famine: PALTEM (parameters to assess long-term effects of malnutrition). View Full-Text
Keywords: environmental epigenetics; DNA methylation; life-stage exposure; famine; risk assessment environmental epigenetics; DNA methylation; life-stage exposure; famine; risk assessment
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Moraru, A.; De Almeida, M.M.; Degryse, J.-M. PALTEM: What Parameters Should Be Collected in Disaster Settings to Assess the Long-Term Outcomes of Famine? Int. J. Environ. Res. Public Health 2018, 15, 857.

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