Next Article in Journal
The Potential of Integrating Provitamin A-Biofortified Maize in Smallholder Farming Systems to Reduce Malnourishment in South Africa
Next Article in Special Issue
Reference Intervals for Urinary Cotinine Levels and the Influence of Sampling Time and Other Predictors on Its Excretion Among Italian Schoolchildren
Previous Article in Journal
Convergence in Sleep Time Accomplished? Gender Gap in Sleep Time for Middle-Aged Adults in Korea
Previous Article in Special Issue
A Stratified Meta-Analysis of the Association between Exposure to Environmental Tobacco Smoke during Childhood and Adulthood and Urothelial Bladder Cancer Risk
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle

Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy

1
INAIL, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Via di Fontana Candida 1, Monteporzio Catone, 00078 Rome, Italy
2
Lazio Regional Health Service, Department of Epidemiology, Via Cristoforo Colombo 112, 00147 Rome, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(4), 804; https://doi.org/10.3390/ijerph15040804
Received: 6 March 2018 / Revised: 13 April 2018 / Accepted: 17 April 2018 / Published: 19 April 2018
(This article belongs to the Special Issue Environmental Tobacco Smoke: Exposure and Effects)
  |  
PDF [501 KB, uploaded 3 May 2018]
  |  

Abstract

Background: Urinary cotinine, a metabolite of nicotine, is a marker of tobacco smoke exposure. A cutoff value for cotinine concentration can be set to distinguish smokers from non-smokers, independently from self-declared status. Method: Cotinine was determined by isotopic dilution High Performance Liquid Chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) between 2013 and 2014 on urine samples of a population of 1075 subjects. Results: 296 subjects have a cotinine level higher than 100 μg/g of creatinine (cutoff), with a median cotinine concentration of 1504.70 μg/g of creatinine. The mean is 27.5% of smokers and 60.5% in this group are females. The median value for non-smokers is 5.6 μg/g of creatinine. Two hundred and seventy-five subjects declared to be smokers in the questionnaire, but 6 (2.2%) present urinary cotinine levels lower than cutoff; 800 subjects declared to be non-smokers, but 26 of them presented urinary cotinine levels that were higher than the cutoff (3.3%). Conclusion: Using the cutoff of 100 μg/g, the misclassification of smokers resulted to be 2.2%, indicating that the selected value is suitable for studying the human exposures to environmental and occupational pollutants, including those produced by smoking. View Full-Text
Keywords: biomarkers; urinary cotinine; environmental tobacco smoke; smoking; cutoff; HPLC-MS/MS biomarkers; urinary cotinine; environmental tobacco smoke; smoking; cutoff; HPLC-MS/MS
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Paci, E.; Pigini, D.; Bauleo, L.; Ancona, C.; Forastiere, F.; Tranfo, G. Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy. Int. J. Environ. Res. Public Health 2018, 15, 804.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top