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Int. J. Environ. Res. Public Health 2018, 15(4), 723;

Concerns about Quadrupole ICP-MS Lead Isotopic Data and Interpretations in the Environment and Health Fields

Energy and Environmental Research Centre, Department of Environmental Sciences, Macquarie University, Sydney, NSW 2109, Australia
CSIRO Energy Flagship, North Ryde, NSW 2113, Australia
Department of Geological Sciences, University of Florida, Gainesville, FL 32605, USA
Department of Geosciences, University of Texas at Dallas, Richardson, TX 75080, USA
Marine Biological Laboratory, Woods Hole, MA 02543, USA
Author to whom correspondence should be addressed.
Received: 9 March 2018 / Revised: 28 March 2018 / Accepted: 8 April 2018 / Published: 11 April 2018
(This article belongs to the Special Issue Isotopic Fingerprinting of Metals: From Environment to Human Body)
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There has been a massive increase in recent years of the use of lead (Pb) isotopes in attempts to better understand sources and pathways of Pb in the environment and in man or experimental animals. Unfortunately, there have been many cases where the quality of the isotopic data, especially that obtained by quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS), are questionable, resulting in questionable identification of potential sources, which, in turn, impacts study interpretation and conclusions. We present several cases where the isotopic data have compromised interpretation because of the use of only the major isotopes 208Pb/206Pb and 207Pb/206Pb, or their graphing in other combinations. We also present some examples comparing high precision data from thermal ionization (TIMS) or multi-collector plasma mass spectrometry (MC-ICP-MS) to illustrate the deficiency in the Q-ICP-MS data. In addition, we present cases where Pb isotopic ratios measured on Q-ICP-MS are virtually impossible for terrestrial samples. We also evaluate the Pb isotopic data for rat studies, which had concluded that Pb isotopic fractionation occurs between different organs and suggest that this notion of biological fractionation of Pb as an explanation for isotopic differences is not valid. Overall, the brief review of these case studies shows that Q-ICP-MS as commonly practiced is not a suitable technique for precise and accurate Pb isotopic analysis in the environment and health fields. View Full-Text
Keywords: lead isotopes; ICP-MS; TIMS; MC-ICP-MS; environment; humans; rats; fractionation lead isotopes; ICP-MS; TIMS; MC-ICP-MS; environment; humans; rats; fractionation

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Gulson, B.; Kamenov, G.D.; Manton, W.; Rabinowitz, M. Concerns about Quadrupole ICP-MS Lead Isotopic Data and Interpretations in the Environment and Health Fields. Int. J. Environ. Res. Public Health 2018, 15, 723.

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