Body Mass Index and Helicobacter pylori among Obese and Non-Obese Patients in Najran, Saudi Arabia: A Case-Control Study
Abstract
:1. Introduction
2. Material and Methods
2.1. Study Design and Setting
2.2. Subjects’ Recruitment and Inclusion and Exclusion Criteria
2.3. Variables and Clinical Procedures
2.4. Ethical Considerations
2.5. Statistical Analysis
3. Results
3.1. Sample Characteristics and Distribution of HPPI between and within Obese and Non-Obese
3.2. Multivariable Analyses of Adjusted Factors of HPPI
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
- Hooi, J.K.Y.; Lai, W.Y.; Ng, W.K.; Suen, M.M.Y.; Underwood, F.E.; Tanyingoh, D.; Malfertheiner, P.; Graham, D.Y.; Wong, V.W.S.; Wu, J.C.Y.; et al. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-analysis. Gastroenterology 2017, 153, 420–429. [Google Scholar] [CrossRef] [PubMed]
- Pellicano, R.; Ribaldone, D.G.; Fagoonee, S.; Astegiano, M.; Saracco, G.M.; Megraud, F. A 2016 panorama of Helicobacter pylori infection: Key messages for clinicians. Panminerva Med. 2016, 58, 304–317. [Google Scholar] [PubMed]
- Boone-Heinonen, J.; Gordon-Larsen, P.; Kiefe, C.I.; Shikany, J.M.; Lewis, C.E.; Popkin, B.M. Fast food restaurants and food stores: Longitudinal associations with diet in young to middle-aged adults: The CARDIA study. Arch. Intern. Med. 2011, 171, 1162–1170. [Google Scholar] [CrossRef] [PubMed]
- Singh, M.; Kirchengast, S. Obesity prevalence and nutritional habits among Indian women: A comparison between Punjabi women living in India and Punjabi migrants in Vienna, Austria. Anthropol. Anz. 2011, 68, 239–251. [Google Scholar] [CrossRef] [PubMed]
- Zillikens, M.C.; van Meurs, J.B.; Rivadeneira, F.; Amin, N.; Hofman, A.; Oostra, B.A.; Sijbrands, E.J.; Witteman, J.C.; Pols, H.A.; van Duijn, C.M.; et al. SIRT1 genetic variation is related to BMI and risk of obesity. Diabetes 2009, 58, 2828–2834. [Google Scholar] [CrossRef] [PubMed]
- Lender, N.; Talley, N.J.; Enck, P.; Haag, S.; Zipfel, S.; Morrison, M.; Holtmann, G.J. Review article: Associations between Helicobacter pylori and obesity—An ecological study. Aliment. Pharmacol. Ther. 2014, 40, 24–31. [Google Scholar] [CrossRef] [PubMed]
- Kamada, T.; Sugiu, K.; Haruma, K. Development of obesity and hyperlipidemia after eradication of Helicobacter pylori. Nihon Rinsho 2005, 63 (Suppl. 1), 536–538. [Google Scholar] [PubMed]
- Lane, J.A.; Murray, L.J.; Harvey, I.M.; Donovan, J.L.; Nair, P.; Harvey, R.F. Randomised clinical trial: Helicobacter pylori eradication is associated with a significantly increased body mass index in a placebo-controlled study. Aliment. Pharmacol. Ther. 2011, 33, 922–929. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Al-Akwaa, A.M. Prevalence of Helicobacter pylori infection in a group of morbidly obese Saudi patients undergoing bariatric surgery: A preliminary report. Saudi J. Gastroenterol. 2010, 16, 264–267. [Google Scholar] [CrossRef] [PubMed]
- Papasavas, P.K.; Gagne, D.J.; Donnelly, P.E.; Salgado, J.; Urbandt, J.E.; Burton, K.K.; Caushaj, P.F. Prevalence of Helicobacter pylori infection and value of preoperative testing and treatment in patients undergoing laparoscopic Roux-en-Y gastric bypass. Surg. Obes. Relat. Dis. 2008, 4, 383–388. [Google Scholar] [CrossRef] [PubMed]
- Xu, C.; Yan, M.; Sun, Y.; Joo, J.; Wan, X.; Yu, C.; Wang, Q.; Shen, C.; Chen, P.; Li, Y.; et al. Prevalence of Helicobacter pylori infection and its relation with body mass index in a Chinese population. Helicobacter 2014, 19, 437–442. [Google Scholar] [CrossRef] [PubMed]
- Alqarni, S.S.M. A Review of Prevalence of Obesity in Saudi Arabia. J. Obes. Eat. Disord. 2016. [Google Scholar] [CrossRef]
- Al-Moagel, M.A.; Evans, D.G.; Abdulghani, M.E.; Adam, E.; Evans, D.J., Jr.; Malaty, H.M.; Graham, D.Y. Prevalence of Helicobacter (formerly Campylobacter) pylori infection in Saudia Arabia, and comparison of those with and without upper gastrointestinal symptoms. Am. J. Gastroenterol. 1990, 85, 944–948. [Google Scholar] [PubMed]
- Elsawaf, Z.M.; Albasri, A.M.; Hussainy, A.S.; Alhujaily, A.S. Histopathological pattern of benign endoscopic gastric biopsies in Western Saudi Arabia: A review of 1236 cases. J. Pak. Med. Assoc. 2017, 67, 252–255. [Google Scholar] [PubMed]
- Khan, A.R. An age- and gender-specific analysis of H. Pylori infection. Ann. Saudi Med. 1998, 18, 6–8. [Google Scholar] [CrossRef] [PubMed]
- Mohamed, A.E.; Al-Karawi, M.A.; Al-Jumah, A.A.; Ahmed, A.M.; Shariq, S.; Yasawy, M.I.; Haleem, A. Helicobacter pylori: Prevalence in 352 consecutive patients with dyspepsia. Ann. Saudi Med. 1994, 14, 134–135. [Google Scholar] [CrossRef] [PubMed]
- Rashed, R.S.; Ayoola, E.A.; Mofleh, I.A.; Chowdhury, M.N.; Mahmood, K.; Faleh, F.Z. Helicobacter pylori and dyspepsia in an Arab population. Trop. Geogr. Med. 1992, 44, 304–307. [Google Scholar] [PubMed]
- Almadi, M.A.; Aljebreen, A.M.; Tounesi, F.A.; Abdo, A.A. Helicobacter pylori prevalence among medical students in a high endemic area. Saudi Med. J. 2007, 28, 896–898. [Google Scholar] [PubMed]
- Meyer, S.B.; Thompson, C.; Hakendorf, P.; Horwood, C.; McNaughton, D.; Gray, J.; Ward, P.R.; Mwanri, L.; Booth, S.; Kow, L.; et al. Bariatric surgery revisions and private health insurance. Obes. Res. Clin. Pract. 2017, 11, 616–621. [Google Scholar] [CrossRef] [PubMed]
- Csendes, A.; Burgos, A.M.; Smok, G.; Beltran, M. Endoscopic and histologic findings of the foregut in 426 patients with morbid obesity. Obes. Surg. 2007, 17, 28–34. [Google Scholar] [CrossRef] [PubMed]
- Azagury, D.; Dumonceau, J.M.; Morel, P.; Chassot, G.; Huber, O. Preoperative work-up in asymptomatic patients undergoing Roux-en-Y gastric bypass: Is endoscopy mandatory? Obes. Surg. 2006, 16, 1304–1311. [Google Scholar] [CrossRef] [PubMed]
- Ramaswamy, A.; Lin, E.; Ramshaw, B.J.; Smith, C.D. Early effects of Helicobacter pylori infection in patients undergoing bariatric surgery. Arch. Surg. 2004, 139, 1094–1096. [Google Scholar] [CrossRef] [PubMed]
- Schirmer, B.; Erenoglu, C.; Miller, A. Flexible endoscopy in the management of patients undergoing Roux-en-Y gastric bypass. Obes. Surg. 2002, 12, 634–638. [Google Scholar] [CrossRef] [PubMed]
- Vanek, V.W.; Catania, M.; Triveri, K.; Woodruff, R.W., Jr. Retrospective review of the preoperative biliary and gastrointestinal evaluation for gastric bypass surgery. Surg. Obes. Relat. Dis. 2006, 2, 13–17. [Google Scholar] [CrossRef] [PubMed]
- Mechanick, J.I.; Youdim, A.; Jones, D.B.; Garvey, W.T.; Hurley, D.L.; McMahon, M.M.; Heinberg, L.J.; Kushner, R.; Adams, T.D.; Shikora, S.; et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient—2013 update: Cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery. Obesity 2013, 21 (Suppl. 1), S1–S27. [Google Scholar]
- Sauerland, S.; Angrisani, L.; Belachew, M.; Chevallier, J.M.; Favretti, F.; Finer, N.; Fingerhut, A.; Garcia Caballero, M.; Guisado Macias, J.A.; Mittermair, R.; et al. Obesity surgery: Evidence-based guidelines of the European Association for Endoscopic Surgery (EAES). Surg. Endosc. 2005, 19, 200–221. [Google Scholar] [CrossRef] [PubMed]
- WHO. BMI Classification; WHO: Geneva, Switzerland, 2000. [Google Scholar]
- Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health. Obes. Res. 1998, 6 (Suppl. 2), S51–S209. [Google Scholar]
- Ekesbo, R.; Nilsson, P.M.; Lindholm, L.H.; Persson, K.; Wadstrom, T. Combined seropositivity for H. pylori and C. pneumoniae is associated with age, obesity and social factors. J. Cardiovasc. Risk 2000, 7, 191–195. [Google Scholar] [CrossRef] [PubMed]
- Gerig, R.; Ernst, B.; Wilms, B.; Thurnheer, M.; Schultes, B. Preoperative nutritional deficiencies in severely obese bariatric candidates are not linked to gastric Helicobacter pylori infection. Obes. Surg. 2013, 23, 698–702. [Google Scholar] [CrossRef] [PubMed]
- Arslan, E.; Atilgan, H.; Yavasoglu, I. The prevalence of Helicobacter pylori in obese subjects. Eur. J. Intern. Med. 2009, 20, 695–697. [Google Scholar] [CrossRef] [PubMed]
- Karima, T.M.; Bukhari, S.Z.; Ghais, M.A.; Fatani, M.I.; Hussain, W.M. Prevalence of Helicobacter pylori infection in patients with peptic ulcer diseases. Saudi Med. J. 2006, 27, 621–626. [Google Scholar] [PubMed]
- Morad, N.A.; Ahmed, M.E.; Al-Wabel, A.; Foli, A.K. Helicobacter pylori associated dyspepsia in 208 patients from southern Saudi Arabia. Ann. Saudi Med. 1993, 13, 340–343. [Google Scholar] [CrossRef] [PubMed]
- Erim, T.; Cruz-Correa, M.R.; Szomstein, S.; Velis, E.; Rosenthal, R. Prevalence of Helicobacter pylori seropositivity among patients undergoing bariatric surgery: A preliminary study. World J. Surg. 2008, 32, 2021–2025. [Google Scholar] [CrossRef] [PubMed]
- Smith, S.; Jolaiya, T.; Fowora, M.; Palamides, P.; Ngoka, F.; Bamidele, M.; Lesi, O.; Onyekwere, C.; Ugiagbe, R.; Agbo, I.; et al. Clinical and Socio- Demographic Risk Factors for Acquisition of Helicobacter pylori Infection in Nigeria. Asian Pac. J. Cancer Prev. 2018, 19, 1851–1857. [Google Scholar] [PubMed]
- Carabotti, M.; D’Ercole, C.; Iossa, A.; Corazziari, E.; Silecchia, G.; Severi, C. Helicobacter pylori infection in obesity and its clinical outcome after bariatric surgery. World J. Gastroenterol. 2014, 20, 647–653. [Google Scholar] [CrossRef] [PubMed]
Variables | Mean ± SD or N (%) | OR (95% CI) | p-Value | |
---|---|---|---|---|
Obese (Cases) | Non-Obese (Controlled) | |||
Age | 31.54 ± 8.27 | 30.90 ± 7.93 | - | 0.307 |
Gender | ||||
Male | 226 (66.5) | 219 (64.4) | ||
Female | 114 (33.5) | 121 (35.6) | 0.93 (0.67–1.25) | 0.572 |
BMI | 48.04 ± 8.10 | 23.13 ± 3.80 | - | 0.0005 |
HPPI | 225 (66.2) | 169 (49.7) | 1.98 (1.45–2.70) | 0.0005 |
HPPI in male | 146 (58.4) | 104 (41.6) | 2.02 (1.38–2.95) | 0.0005 |
HPPI in female | 79 (54.9) | 65 (45.1) | 1.95 (1.14–3.32) | 0.014 |
Explanatory Variables | Wald | AOR (95% CI) * | p-Value |
---|---|---|---|
Age | 0.371 | 0.99 (0.98–1.03) | 0.542 |
Gender | |||
Male | 1 | ||
Female | 2.11 | 1.28 (0.92–1.77) | 0.146 |
BMI | 13.67 | 1.02 (1.01–1.03) | 0.0005 |
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Al-Zubaidi, A.M.; Alzobydi, A.H.; Alsareii, S.A.; Al-Shahrani, A.; Alzaman, N.; Kassim, S. Body Mass Index and Helicobacter pylori among Obese and Non-Obese Patients in Najran, Saudi Arabia: A Case-Control Study. Int. J. Environ. Res. Public Health 2018, 15, 2586. https://doi.org/10.3390/ijerph15112586
Al-Zubaidi AM, Alzobydi AH, Alsareii SA, Al-Shahrani A, Alzaman N, Kassim S. Body Mass Index and Helicobacter pylori among Obese and Non-Obese Patients in Najran, Saudi Arabia: A Case-Control Study. International Journal of Environmental Research and Public Health. 2018; 15(11):2586. https://doi.org/10.3390/ijerph15112586
Chicago/Turabian StyleAl-Zubaidi, Ali M., Abdo H. Alzobydi, Saeed A. Alsareii, AbdulazizTurky Al-Shahrani, Naweed Alzaman, and Saba Kassim. 2018. "Body Mass Index and Helicobacter pylori among Obese and Non-Obese Patients in Najran, Saudi Arabia: A Case-Control Study" International Journal of Environmental Research and Public Health 15, no. 11: 2586. https://doi.org/10.3390/ijerph15112586