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Arylesterase Phenotype-Specific Positive Association Between Arylesterase Activity and Cholinesterase Specific Activity in Human Serum

1
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
2
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
3
Mercy Medical Center, Baltimore, MD 21202, USA
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2014, 11(2), 1422-1443; https://doi.org/10.3390/ijerph110201422
Received: 3 June 2013 / Revised: 27 December 2013 / Accepted: 15 January 2014 / Published: 27 January 2014
Context: Cholinesterase (ChE) specific activity is the ratio of ChE activity to ChE mass and, as a biomarker of exposure to cholinesterase inhibitors, has a potential advantage over simple ChE activity. Objective: To examine the association of several potential correlates (serum arylesterase/paraoxonase activity, serum albumin, sex, age, month of blood collection, and smoking) with plasma ChE specific activity. Methods: We analyzed data from 195 cancer-free controls from a nested case-control study, accounting for potential confounding. Results: Arylesterase activity had an independent, statistically significant positive association with ChE specific activity, and its magnitude was the greatest for the arylesterase phenotype corresponding to the QQ PON1192 genotype followed by phenotypes corresponding to QR and RR genotypes. Serum albumin was positively associated with ChE specific activity. Conclusions: Plasma arylesterase activity was positively associated with plasma ChE specific activity. This observation is consistent with protection conferred by a metabolic phenotype resulting in reduced internal dose. View Full-Text
Keywords: pseudocholinesterase; arylesterase; paraoxonase; genetic polymorphism; biomarkers; internal dose; albumin pseudocholinesterase; arylesterase; paraoxonase; genetic polymorphism; biomarkers; internal dose; albumin
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Aoki, Y.; Helzlsouer, K.J.; Strickland, P.T. Arylesterase Phenotype-Specific Positive Association Between Arylesterase Activity and Cholinesterase Specific Activity in Human Serum. Int. J. Environ. Res. Public Health 2014, 11, 1422-1443.

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