Pseudonocardians A–C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp. SCSIO 01299
Abstract
:1. Introduction
2. Results and Discussion
2.1. Taxonomy of the Producing Strain
2.2. Structural Elucidation
2.3. Biological Activities
2.4. Discussion
3. Experimental Section
3.1. General Experimental Procedures
3.2. Microbiological Material
3.3. Extraction and Isolation
3.4. Characterization Data
3.5. Antibacterial and Cytotoxic Assay
4. Conclusions
Acknowledgments
References and Notes
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No. | 1 a | 2 b | 2 c | 3 b | ||||
---|---|---|---|---|---|---|---|---|
δH (J in Hz) | δC | δH (J in Hz) | δC | δH (J in Hz) | δC | δH (J in Hz) | δC | |
2 | 161.4 s | 164.5 s | 161.0 s | 164.5 s | ||||
3 | 6.82 d (1.0) | 126.8 d | 6.48, s | 121.4 d | 6.39, d (1.0) | 119.8 d | 6.49, d (1.0) | 121.4 d |
4 | 149.0 s | 153.5s | 150.6 s | 153.5 s | ||||
5 | 182.4 s * | 183.5 s | 181.9 s | 183.6 s | ||||
6 | 150.5 s | 153.8 s | 150.1 s | 153.6 s | ||||
7 | 6.78 d (1.0) | 127.1 d | 6.32, s | 122.6 d | 6.24, d (1.0) | 121.2 d | 6.30, d (1.0) | 122.6 d |
8 | 162.4 s | 162.8 s | 159.3 s | 163.0 s | ||||
10 | 176.9 s * | 72.7 s | 70.8 s | 72.8 s | ||||
11 | 141.4 s | 151.8 s | 149.9 s | 152.0 s | ||||
12 | 118.2 s | 117.8 s | 114.7 s | 117.8 s | ||||
13 | 114.9 s | 110.8 s | 107.8 s | 111.0 s | ||||
14 | 141.7 s | 157.0 s | 155.8 s | 156.9 s | ||||
15 | 4.01, s | 33.9 q | 3.90, s | 34.1 q | 3.71, s | 32.6 q | 3.90, s | 34.2 q |
16 | 2.59, d (1.0) | 23.0 q | 2.57, s | 23.6 q | 2.44, d (1.0) | 22.7 q | 2.55, d, (1.0) | 23.5 q |
17 | 2.55, d (1.0) | 22.1 q | 2.58, s | 21.3 q | 2.45, d (1.0) | 20.5 q | 2.59, d (1.0) | 21.3 q |
18 | 2.71, d (13.5), | 52.4 t | 2.62, d (13.5), | 50.8 t | 2.51, d (13.8), | 47.9 t | ||
3.30, d (13.5) | 3.13, d (13.5) | 3.41, d (13.8) | ||||||
19 | 97.6 s | 95.5 s | 100.8 s | |||||
20 | 2.19, s | 26.5 q | 2.03, s | 25.9 q | 2.41, dd (7.5, 14.0), | 31.6 t | ||
2.84, dd (7.5, 14.0) | ||||||||
21 | 1.22, t (7.5) | 9.3 q |
Compounds | MIC (μg mL–1) | IC50 (μM) | ||||
---|---|---|---|---|---|---|
B. thuringensis SCSIO BT01 | S. aureus ATCC 29213 | E. faecalis ATCC 29212 | SF-268 | MCF-7 | NCI-H460 | |
1 | 1 | 1 | 1 | 0.022 | 0.015 | 0.080 |
2 | 4 | 4 | 2 | 0.028 | 0.027 | 0.209 |
3 | 2 | 2 | 2 | 0.022 | 0.021 | 0.177 |
4 | >128 | >128 | >128 | 6.70 | 8.02 | 43.28 |
Cisplatin | ND a | ND a | ND a | 3.99 | 9.24 | 1.53 |
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Li, S.; Tian, X.; Niu, S.; Zhang, W.; Chen, Y.; Zhang, H.; Yang, X.; Zhang, W.; Li, W.; Zhang, S.; et al. Pseudonocardians A–C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp. SCSIO 01299. Mar. Drugs 2011, 9, 1428-1439. https://doi.org/10.3390/md9081428
Li S, Tian X, Niu S, Zhang W, Chen Y, Zhang H, Yang X, Zhang W, Li W, Zhang S, et al. Pseudonocardians A–C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp. SCSIO 01299. Marine Drugs. 2011; 9(8):1428-1439. https://doi.org/10.3390/md9081428
Chicago/Turabian StyleLi, Sumei, Xinpeng Tian, Siwen Niu, Wenjun Zhang, Yuchan Chen, Haibo Zhang, Xianwen Yang, Weimin Zhang, Wenjun Li, Si Zhang, and et al. 2011. "Pseudonocardians A–C, New Diazaanthraquinone Derivatives from a Deap-Sea Actinomycete Pseudonocardia sp. SCSIO 01299" Marine Drugs 9, no. 8: 1428-1439. https://doi.org/10.3390/md9081428