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Mar. Drugs 2011, 9(10), 1955-1968; https://doi.org/10.3390/md9101955

Bioactive Cembranoids from the Soft Coral Sinularia crassa

1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
Chinese Medicinal Research and Development Center, China Medical University and Hospital, Taichung 404, Taiwan
3
Asian Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
4
College of Chinese Medicine, China Medical University, Taichung 404, Taiwan
5
Institute of Oceanography, National Taiwan University, Taipei, Taiwan
*
Author to whom correspondence should be addressed.
Received: 18 August 2011 / Revised: 26 September 2011 / Accepted: 9 October 2011 / Published: 17 October 2011
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Abstract

Eight new cembranoids, crassarines A–H (18) were isolated from the Formosan soft coral Sinularia crassa. Compounds 13 represent the rare cembranoids with a 1,12-oxa-bridged tetrahydrofuran ring, while 4 and 5 are the firstly discovered 1,11-oxa-bridged tetrahydropyranocembranoids. The absolute configuration of 6 was determined using the Mosher’s method. Compounds 6 and 8 were found to significantly inhibit the expression of both pro-inflammatory iNOS and COX-2 proteins at 10 µM, respectively, while compounds 48 were found to be non-cytotoxic toward the selected human liver cancer cells. View Full-Text
Keywords: Sinularia crassa; crassarines A–H; anti-inflammatory Sinularia crassa; crassarines A–H; anti-inflammatory
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Chao, C.-H.; Chou, K.-J.; Huang, C.-Y.; Wen, Z.-H.; Hsu, C.-H.; Wu, Y.-C.; Dai, C.-F.; Sheu, J.-H. Bioactive Cembranoids from the Soft Coral Sinularia crassa. Mar. Drugs 2011, 9, 1955-1968.

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