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Development of Novel Drugs from Marine Surface Associated Microorganisms

School of Biotechnology and Biomolecular Sciences and Centre for Marine Bio-Innovation, University of New South Wales, Sydney 2052, Australia
Author to whom correspondence should be addressed.
Mar. Drugs 2010, 8(3), 438-459;
Received: 18 January 2010 / Revised: 3 February 2010 / Accepted: 22 February 2010 / Published: 1 March 2010
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes)
While the oceans cover more than 70% of the Earth’s surface, marine derived microbial natural products have been largely unexplored. The marine environment is a habitat for many unique microorganisms, which produce biologically active compounds (“bioactives”) to adapt to particular environmental conditions. For example, marine surface associated microorganisms have proven to be a rich source for novel bioactives because of the necessity to evolve allelochemicals capable of protecting the producer from the fierce competition that exists between microorganisms on the surfaces of marine eukaryotes. Chemically driven interactions are also important for the establishment of cross-relationships between microbes and their eukaryotic hosts, in which organisms producing antimicrobial compounds (“antimicrobials”), may protect the host surface against over colonisation in return for a nutrient rich environment. As is the case for bioactive discovery in general, progress in the detection and characterization of marine microbial bioactives has been limited by a number of obstacles, such as unsuitable culture conditions, laborious purification processes, and a lack of de-replication. However many of these limitations are now being overcome due to improved microbial cultivation techniques, microbial (meta-) genomic analysis and novel sensitive analytical tools for structural elucidation. Here we discuss how these technical advances, together with a better understanding of microbial and chemical ecology, will inevitably translate into an increase in the discovery and development of novel drugs from marine microbial sources in the future. View Full-Text
Keywords: marine epibiotic microoorganisms; bioactive; antimicrobial; natural products marine epibiotic microoorganisms; bioactive; antimicrobial; natural products
MDPI and ACS Style

Penesyan, A.; Kjelleberg, S.; Egan, S. Development of Novel Drugs from Marine Surface Associated Microorganisms. Mar. Drugs 2010, 8, 438-459.

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