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Article

In Vitro and In Vivo Dendritic Cell Immune Stimulation Effect of Low Molecular Weight Fucoidan from New Zealand Undaria pinnatifida

1
Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China
2
School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 1010, New Zealand
3
School of Public Health and Interdisciplinary Studies, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 0627, New Zealand
4
Maurice Wilkins Centre for Molecular Biodiscovery, Auckland 1010, New Zealand
*
Authors to whom correspondence should be addressed.
Academic Editor: Marc Diederich
Mar. Drugs 2022, 20(3), 197; https://doi.org/10.3390/md20030197
Received: 15 January 2022 / Revised: 19 February 2022 / Accepted: 5 March 2022 / Published: 8 March 2022
(This article belongs to the Special Issue Pre-clinical Marine Drug Discovery Ⅱ)
Low molecular weight fucoidan (LMWF) has been reported to have immunomodulation effects through the increase of the activation and function of macrophages. In this study, the regulating effect of LMWF from Undaria pinnatifida grown in New Zealand on dendritic cells (DCs) was investigated. We discovered that LMWF could stimulate DCs’ maturation and migration, as well as CD4+ and CD8+ T cells’ proliferation in vitro. We proved that this immune promoting activity is activated through TLR4 and its downstream MAPK and NF–κB signaling pathways. Further in vivo (mouse model) investigation showed that LMWF has a strong immunological boosting effect, such as facilitating the proliferation of immune cells and increasing the index of immune organs. These findings suggest that LMWF has a positive immunomodulatory effect and is a promising candidate to supplement cancer immunotherapy. View Full-Text
Keywords: low molecular weight fucoidan (LMWF); dendritic cells; immune stimulation; Undaria pinnatifida; New Zealand low molecular weight fucoidan (LMWF); dendritic cells; immune stimulation; Undaria pinnatifida; New Zealand
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MDPI and ACS Style

Liu, L.; Yang, X.; Yuan, P.; Cai, S.; Bao, J.; Zhao, Y.; Aimaier, A.; Aipire, A.; Lu, J.; Li, J. In Vitro and In Vivo Dendritic Cell Immune Stimulation Effect of Low Molecular Weight Fucoidan from New Zealand Undaria pinnatifida. Mar. Drugs 2022, 20, 197. https://doi.org/10.3390/md20030197

AMA Style

Liu L, Yang X, Yuan P, Cai S, Bao J, Zhao Y, Aimaier A, Aipire A, Lu J, Li J. In Vitro and In Vivo Dendritic Cell Immune Stimulation Effect of Low Molecular Weight Fucoidan from New Zealand Undaria pinnatifida. Marine Drugs. 2022; 20(3):197. https://doi.org/10.3390/md20030197

Chicago/Turabian Style

Liu, Litong, Xu Yang, Pengfei Yuan, Shanshan Cai, Jing Bao, Yanan Zhao, Alimu Aimaier, Adila Aipire, Jun Lu, and Jinyao Li. 2022. "In Vitro and In Vivo Dendritic Cell Immune Stimulation Effect of Low Molecular Weight Fucoidan from New Zealand Undaria pinnatifida" Marine Drugs 20, no. 3: 197. https://doi.org/10.3390/md20030197

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