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Anti-Alzheimer’s Molecules Derived from Marine Life: Understanding Molecular Mechanisms and Therapeutic Potential

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Department of Pharmacy, Brac University, Dhaka 1212, Bangladesh
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Department of Pharmacy, Southeast University, Dhaka 1213, Bangladesh
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Pharmakon Neuroscience Research Network, Dhaka 1207, Bangladesh
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Research Unit, Induced Resistance and Plant Bioprotection, USC INRAe 1488, SFR Condorcet FR CNRS 3417, Faculty of Sciences, University of Reims Champagne-Ardenne, P.O. Box 1039, CEDEX 2, 51687 Reims, France
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Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh
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Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh
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Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11474, Saudi Arabia
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Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt
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Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt
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Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo, Ourense Campus, E32004 Ourense, Spain
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Authors to whom correspondence should be addressed.
Academic Editors: Amélia Pilar Rauter and Narcisa M. Bandarra
Mar. Drugs 2021, 19(5), 251; https://doi.org/10.3390/md19050251
Received: 27 February 2021 / Revised: 19 April 2021 / Accepted: 26 April 2021 / Published: 28 April 2021
(This article belongs to the Special Issue Anti-Alzheimer Agents from Marine Sources)
Alzheimer’s disease (AD) is a devastating neurodegenerative disease and the most common cause of dementia. It has been confirmed that the pathological processes that intervene in AD development are linked with oxidative damage to neurons, neuroinflammation, tau phosphorylation, amyloid beta (Aβ) aggregation, glutamate excitotoxicity, and cholinergic deficit. Still, there is no available therapy that can cure AD. Available therapies only manage some of the AD symptoms at the early stages of AD. Various studies have revealed that bioactive compounds derived from marine organisms and plants can exert neuroprotective activities with fewer adverse events, as compared with synthetic drugs. Furthermore, marine organisms have been identified as a source of novel compounds with therapeutic potential. Thus, there is a growing interest regarding bioactive compounds derived from marine sources that have anti-AD potentials. Various marine drugs including bryostatin-1, homotaurine, anabaseine and its derivative, rifampicins, anhydroexfoliamycin, undecylprodigioisin, gracilins, 13-desmethyl spirolide-C, and dictyostatin displayed excellent bioavailability and efficacy against AD. Most of these marine drugs were found to be well-tolerated in AD patients, along with no significant drug-associated adverse events. In this review, we focus on the drugs derived from marine life that can be useful in AD treatment and also summarize the therapeutic agents that are currently used to treat AD. View Full-Text
Keywords: Alzheimer’s disease; Aβ aggregation; tau phosphorylation; bryostatin-1; marine life; marine drugs Alzheimer’s disease; Aβ aggregation; tau phosphorylation; bryostatin-1; marine life; marine drugs
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MDPI and ACS Style

Kabir, M.T.; Uddin, M.S.; Jeandet, P.; Emran, T.B.; Mitra, S.; Albadrani, G.M.; Sayed, A.A.; Abdel-Daim, M.M.; Simal-Gandara, J. Anti-Alzheimer’s Molecules Derived from Marine Life: Understanding Molecular Mechanisms and Therapeutic Potential. Mar. Drugs 2021, 19, 251. https://doi.org/10.3390/md19050251

AMA Style

Kabir MT, Uddin MS, Jeandet P, Emran TB, Mitra S, Albadrani GM, Sayed AA, Abdel-Daim MM, Simal-Gandara J. Anti-Alzheimer’s Molecules Derived from Marine Life: Understanding Molecular Mechanisms and Therapeutic Potential. Marine Drugs. 2021; 19(5):251. https://doi.org/10.3390/md19050251

Chicago/Turabian Style

Kabir, Md. T., Md. S. Uddin, Philippe Jeandet, Talha B. Emran, Saikat Mitra, Ghadeer M. Albadrani, Amany A. Sayed, Mohamed M. Abdel-Daim, and Jesus Simal-Gandara. 2021. "Anti-Alzheimer’s Molecules Derived from Marine Life: Understanding Molecular Mechanisms and Therapeutic Potential" Marine Drugs 19, no. 5: 251. https://doi.org/10.3390/md19050251

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