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Article

Effects of a Fish Oil Rich in Docosahexaenoic Acid on Cardiometabolic Risk Factors and Oxidative Stress in Healthy Rats

1
Functional Nutrition, Oxidation and Cardiovascular Diseases Research Group (NFOC-SALUT), Pharmacology Unit, Department of Basic Medical Sciences, Universitat Rovira i Virgili, C/Sant Llorenç 21, E-43201 Reus, Spain
2
Chemistry of Marine Products, Department of Food Technology, Institute of Marine Research (IIM-CSIC), C/Eduardo Cabello 6, E-36208 Vigo, Spain
3
Eldine Patología, C/Plom 32, E-43006 Tarragona, Spain
4
Department of Biological Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), C/Jordi Girona 18-26, E-08034 Barcelona, Spain
5
Department of Cell Biology, Physiology & Immunology, Faculty of Biology, University of Barcelona, Avd/Diagonal 643, E-08028 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Marc Diederich
Mar. Drugs 2021, 19(10), 555; https://doi.org/10.3390/md19100555
Received: 15 September 2021 / Revised: 23 September 2021 / Accepted: 27 September 2021 / Published: 29 September 2021
(This article belongs to the Special Issue Advances in Therapeutic Applications of Fish Oil)
Omega-3 polyunsaturated fatty acids are associated with a lower risk of cardiometabolic diseases. However, docosahexaenoic acid (DHA) is easily oxidized, leading to cellular damage. The present study examined the effects of an increased concentration of DHA in fish oil (80% of total fatty acids) on cardiometabolic risk factors and oxidative stress compared to coconut oil, soybean oil, and fish oil containing eicosapentaenoic acid (EPA) and DHA in a balanced ratio. Forty healthy male Sprague–Dawley rats were supplemented with corresponding oil for 10 weeks. Supplementation with the fish oil containing 80% DHA decreased plasma fat, plasma total cholesterol and muscle fat compared to the coconut oil and the soybean oil. Increasing concentrations of DHA induced incorporation of DHA and EPA in cell membranes and tissues along with a decrease in ω-6 arachidonic acid. The increase in DHA promoted lipid peroxidation, protein carbonylation and antioxidant response. Taken together, the increased concentration of DHA in fish oil reduced fat accumulation compared to the coconut oil and the soybean oil. This benefit was accompanied by high lipid peroxidation and subsequent protein carbonylation in plasma and in liver. In our healthy framework, the slightly higher carbonylation found after receiving fish oil containing 80% DHA might be a protecting mechanism, which fit with the general improvement of antioxidant defense observed in those rats. View Full-Text
Keywords: eicosapentaenoic acid; soybean oil; coconut oil; cholesterol; glucose; inflammation; lipid peroxidation; protein carbonylation eicosapentaenoic acid; soybean oil; coconut oil; cholesterol; glucose; inflammation; lipid peroxidation; protein carbonylation
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MDPI and ACS Style

Miralles-Pérez, B.; Méndez, L.; Nogués, M.R.; Sánchez-Martos, V.; Fortuño-Mar, À.; Ramos-Romero, S.; Hereu, M.; Medina, I.; Romeu, M. Effects of a Fish Oil Rich in Docosahexaenoic Acid on Cardiometabolic Risk Factors and Oxidative Stress in Healthy Rats. Mar. Drugs 2021, 19, 555. https://doi.org/10.3390/md19100555

AMA Style

Miralles-Pérez B, Méndez L, Nogués MR, Sánchez-Martos V, Fortuño-Mar À, Ramos-Romero S, Hereu M, Medina I, Romeu M. Effects of a Fish Oil Rich in Docosahexaenoic Acid on Cardiometabolic Risk Factors and Oxidative Stress in Healthy Rats. Marine Drugs. 2021; 19(10):555. https://doi.org/10.3390/md19100555

Chicago/Turabian Style

Miralles-Pérez, Bernat, Lucía Méndez, Maria Rosa Nogués, Vanessa Sánchez-Martos, Àngels Fortuño-Mar, Sara Ramos-Romero, Mercè Hereu, Isabel Medina, and Marta Romeu. 2021. "Effects of a Fish Oil Rich in Docosahexaenoic Acid on Cardiometabolic Risk Factors and Oxidative Stress in Healthy Rats" Marine Drugs 19, no. 10: 555. https://doi.org/10.3390/md19100555

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