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Chemical Diversity and Biological Activities of Meroterpenoids from Marine Derived-Fungi: A Comprehensive Update

1
The John Innes Centre, Department of Metabolic Biology, Norwich Research Park, Norwich NR4 7UH, UK
2
Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
3
ICBAS-Instituto de Ciências Biomédicas Abel Salazar & CIIMAR, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(6), 317; https://doi.org/10.3390/md18060317
Received: 2 May 2020 / Revised: 6 June 2020 / Accepted: 12 June 2020 / Published: 15 June 2020
Meroterpenoids are a class of hybrid natural products, partially derived from a mixed terpenoid pathway. They possess remarkable structural features and relevant biological and pharmacological activities. Marine-derived fungi are a rich source of meroterpenoids featuring structural diversity varying from simple to complex molecular architectures. A combination of a structural variability and their myriad of bioactivities makes meroterpenoids an interesting class of naturally occurring compounds for chemical and pharmacological investigation. In this review, a comprehensive literature survey covering the period of 2009–2019, with 86 references, is presented focusing on chemistry and biological activities of various classes of meroterpenoids isolated from fungi obtained from different marine hosts and environments. View Full-Text
Keywords: meroterpenoids; marine-derived fungi; biological activities; antibacterial; cytotoxicity; anti-inflammatory meroterpenoids; marine-derived fungi; biological activities; antibacterial; cytotoxicity; anti-inflammatory
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MDPI and ACS Style

El-Demerdash, A.; Kumla, D.; Kijjoa, A. Chemical Diversity and Biological Activities of Meroterpenoids from Marine Derived-Fungi: A Comprehensive Update. Mar. Drugs 2020, 18, 317.

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