Next Article in Journal
First Evidence of the Presence of Anatoxin-A in Sea Figs Associated with Human Food Poisonings in France
Previous Article in Journal
Neosaxitoxin Inhibits the Expression of Inflammation Markers of the M1 Phenotype in Macrophages
Open AccessArticle

Novel Fredericamycin Variant Overproduced by a Streptomycin-Resistant Streptomyces albus subsp. chlorinus Strain

1
Pharmazeutische Biotechnologie, Universität des Saarlandes, 66123 Saarbrücken, Germany
2
Organische Chemie II, Universität Siegen, 57068 Siegen, Germany
3
BASF SE, 67056 Ludwigshafen, Germany
4
Helmholtz-Institut für Pharmazeutische Forschung Saarland, 66123 Saarbrücken, Germany
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(6), 284; https://doi.org/10.3390/md18060284
Received: 30 April 2020 / Revised: 22 May 2020 / Accepted: 27 May 2020 / Published: 28 May 2020
(This article belongs to the Special Issue Marine Anti-infective Agents 2020)
Streptomycetes are an important source of natural products potentially applicable in the pharmaceutical industry. Many of these drugs are secondary metabolites whose biosynthetic genes are very often poorly expressed under laboratory cultivation conditions. In many cases, antibiotic-resistant mutants exhibit increased production of natural drugs, which facilitates the identification and isolation of new substances. In this study, we report the induction of a type II polyketide synthase gene cluster in the marine strain Streptomyces albus subsp. chlorinus through the selection of streptomycin-resistant mutants, resulting in overproduction of the novel compound fredericamycin C2 (1). Fredericamycin C2 (1) is structurally related to the potent antitumor drug lead fredericamycin A. View Full-Text
Keywords: antitumor; fredericamycin; overproduction; secondary metabolites; streptomycetes; streptomycin-resistant; type II PKS antitumor; fredericamycin; overproduction; secondary metabolites; streptomycetes; streptomycin-resistant; type II PKS
Show Figures

Figure 1

MDPI and ACS Style

Rodríguez Estévez, M.; Myronovskyi, M.; Rosenkränzer, B.; Paululat, T.; Petzke, L.; Ristau, J.; Luzhetskyy, A. Novel Fredericamycin Variant Overproduced by a Streptomycin-Resistant Streptomyces albus subsp. chlorinus Strain. Mar. Drugs 2020, 18, 284.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop