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Open AccessArticle

Terpenoids from the Deep-Sea-Derived Fungus Penicillium thomii YPGA3 and Their Bioactivities

1
School of Pharmacy, Henan University, Kaifeng 475004, China
2
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China
3
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
4
Eucommia Ulmoides Cultivation and Utilization of Henan Engineering Laboratory, Kaifeng 475004, China
5
Institute of Ocean and Earth Science (IOES), C308, Institute of Postgraduate Studies Building, University of Malaya, Kuala Lumpur 50603, Malaysia
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(3), 164; https://doi.org/10.3390/md18030164
Received: 27 January 2020 / Revised: 29 February 2020 / Accepted: 12 March 2020 / Published: 16 March 2020
A chemical study of the ethyl acetate (EtOAc) extract from the deep-sea-derived fungus Penicillium thomii YPGA3 led to the isolation of a new austalide meroterpenoid (1) and seven known analogues (28), two new labdane-type diterpenoids (9 and 10) and a known derivative (11). The structures of new compounds 1, 9, and 10 were determined by comprehensive analyses via nuclear magnetic resonance (NMR) and mass spectroscopy (MS) data. The absolute configurations of 1, 9, and 10 were determined by comparisons of experimental electronic circular dichroism (ECD) with the calculated ECD spectra. Compound 1 represented the third example of austalides bearing a hydroxyl group at C-5 instead of the conserved methoxy in other known analogues. To our knowledge, diterpenoids belonging to the labdane-type were discovered from species of Penicillium for the first time. Compound 1 showed cytotoxicity toward MDA-MB-468 cells with an IC50 value of 38.9 μM. Compounds 2 and 11 exhibited inhibition against α-glucosidase with IC50 values of 910 and 525 μM, respectively, being more active than the positive control acarbose (1.33 mM). View Full-Text
Keywords: Penicillium thomii YPGA3; deep-sea-derived fungus; austalide meroterpenoid; labdane-type diterpenoid; bioactivities Penicillium thomii YPGA3; deep-sea-derived fungus; austalide meroterpenoid; labdane-type diterpenoid; bioactivities
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MDPI and ACS Style

Cheng, Z.; Liu, W.; Fan, R.; Han, S.; Li, Y.; Cui, X.; Zhang, J.; Wu, Y.; Lv, X.; Zhang, Y.; Luo, Z.; Alias, S.A.; Xu, W.; Li, Q. Terpenoids from the Deep-Sea-Derived Fungus Penicillium thomii YPGA3 and Their Bioactivities. Mar. Drugs 2020, 18, 164.

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