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Terpenoids from the Deep-Sea-Derived Fungus Penicillium thomii YPGA3 and Their Bioactivities
Open AccessCommunication

Sesquiterpenes and Cyclodepsipeptides from Marine-Derived Fungus Trichoderma longibrachiatum and Their Antagonistic Activities against Soil-Borne Pathogens

by Feng-Yu Du 1,2,†, Guang-Lin Ju 1,†, Lin Xiao 1, Yuan-Ming Zhou 3 and Xia Wu 4,*
1
College of Chemistry and Pharmacy, Qingdao Agricultural University, Qingdao 266109, China
2
Shandong Key Laboratory of Applied Mycology, Qingdao Agricultural University, Qingdao 266109, China
3
Analytical and Testing Center, Qingdao Agricultural University, Qingdao 266109, China
4
Key Lab of Integrated Crop Pest Management of Shandong Province, College of Plant Health and Medicine, Qingdao Agricultural University, Qingdao 266109, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2020, 18(3), 165; https://doi.org/10.3390/md18030165
Received: 24 February 2020 / Revised: 5 March 2020 / Accepted: 11 March 2020 / Published: 16 March 2020
Soil-borne pathogens, including phytopathogenic fungi and root-knot nematodes, could synergistically invade vegetable roots and result in serious economic losses. The genus of Trichoderma has been proven to be a promising reservoir of biocontrol agents in agriculture. In this study, the search for antagonistic metabolites from a marine-derived fungus, Trichoderma longibrachiatum, obtained two structural series of sesquiterpenes 16 and cyclodepsipeptides 79. Notably, the novel 1 was a rare norsesquiterpene characterized by an unprecedented tricyclic-6/5/5-[4.3.1.01,6]-decane skeleton. Their structures were elucidated by extensive spectroscopic analyses, while the absolute configuration of novel 1 was determined by the comparison of experimental and calculated ECD spectra. The novel 1 and known 2 and 3 showed significant antifungal activities against Colletotrichum lagrnarium with MIC values of 8, 16, and 16 μg/mL respectively, even better than those of the commonly used synthetic fungicide carbendazim with 32 μg/mL. They also exhibited antifungal potential against carbendazim-resistant Botrytis cinerea. Cyclodepsipeptides 79 showed moderate nematicidal activities against the southern root-knot nematode (Meloidogyne incognita). This study constitutes the first report on the antagonistic effects of metabolites from T. Longibrachiatum against soil-borne pathogens, also highlighting the integrated antagonistic potential of marine-derived T. Longibrachiatum as a biocontrol agent. View Full-Text
Keywords: marine-derived fungus; sesquiterpenes; cyclodepsipeptides; antagonistic activity marine-derived fungus; sesquiterpenes; cyclodepsipeptides; antagonistic activity
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MDPI and ACS Style

Du, F.-Y.; Ju, G.-L.; Xiao, L.; Zhou, Y.-M.; Wu, X. Sesquiterpenes and Cyclodepsipeptides from Marine-Derived Fungus Trichoderma longibrachiatum and Their Antagonistic Activities against Soil-Borne Pathogens. Mar. Drugs 2020, 18, 165.

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