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Natural Products of Marine Macroalgae from South Eastern Australia, with Emphasis on the Port Phillip Bay and Heads Regions of Victoria

Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study

Pharmacy, School of Medicine, University of Tasmania, Hobart, TAS 7001, Australia
Medical Oncology, Ingham Institute for Applied Medical Research, School of Medicine, Western Sydney University and SWS Clinical School, UNSW, Sydney, NSW 2170, Australia
School of Health Sciences, University of Tasmania, Newnham, TAS 7248, Australia
Marinova Pty Ltd., Cambridge, TAS 7170, Australia
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(3), 143;
Received: 11 February 2020 / Revised: 26 February 2020 / Accepted: 26 February 2020 / Published: 28 February 2020
Fucoidans are a class of fucose-rich sulfated polysaccharides derived from brown macroalgae that exert a range of biological activities in vitro and in vivo. To generate an unbiased assessment of pathways and processes affected by fucoidan, a placebo-controlled double-blind pilot study was performed in healthy volunteers. Blood samples were taken immediately before and 24 h after ingestion of a single dose of 1 g of Undaria pinnatifida fucoidan (UPF) or placebo. Levels of isolated miRNAs were analyzed using Taqman Open Array Human MicroRNA panels. Out of 754 miRNAs screened, UPF affected a total of 53 miRNAs. Pathway analysis using the TALOS data analysis tool predicted 29 different pathways and processes that were largely grouped into cell surface receptor signaling, cancer-related pathways, the majority of which were previously associated with fucoidans. However, this analysis also identified nine pathways and processes that have not been associated with fucoidans before. Overall, this study illustrates that even a single dose of fucoidans has the potential to affect the expression of genes related to fundamental cellular processes. Moreover, it confirms previous data that fucoidans influence immunity, cancer cells, inflammation, and neurological function. View Full-Text
Keywords: fucoidan; clinical; microRNA; anti-inflammatory; anti-cancer fucoidan; clinical; microRNA; anti-inflammatory; anti-cancer
MDPI and ACS Style

Gueven, N.; Spring, K.J.; Holmes, S.; Ahuja, K.; Eri, R.; Park, A.Y.; Fitton, J.H. Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study. Mar. Drugs 2020, 18, 143.

AMA Style

Gueven N, Spring KJ, Holmes S, Ahuja K, Eri R, Park AY, Fitton JH. Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study. Marine Drugs. 2020; 18(3):143.

Chicago/Turabian Style

Gueven, Nuri, Kevin J. Spring, Sandra Holmes, Kiran Ahuja, Raj Eri, Ah Y. Park, and J H. Fitton. 2020. "Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study" Marine Drugs 18, no. 3: 143.

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