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Whole Genome Sequence of Dermacoccus abyssi MT1.1 Isolated from the Challenger Deep of the Mariana Trench Reveals Phenazine Biosynthesis Locus and Environmental Adaptation Factors

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Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
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Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
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Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen, Scotland, AB24 3UE, UK
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School of Life Sciences Pharmacy and Chemistry, Faculty of Science, Engineering and Computing, Kingston University, Kingston upon Thames, Penrhyn Road, KT1 2EE, UK
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School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK
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Centro de Investigacións Científicas Avanzadas (CICA) e Departamento de Química, Facultade de Ciencias, Universidade da Coruña, 15071 A Coruña, Spain
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School of Forensic and Applied Sciences, Faculty of Science and Technology, University of Central Lancashire, PR1 2HE, Preston, UK
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Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(3), 131; https://doi.org/10.3390/md18030131
Received: 17 December 2019 / Revised: 14 February 2020 / Accepted: 21 February 2020 / Published: 25 February 2020
Dermacoccus abyssi strain MT1.1T is a piezotolerant actinobacterium that was isolated from Mariana Trench sediment collected at a depth of 10898 m. The organism was found to produce ten dermacozines (A‒J) that belonged to a new phenazine family and which displayed various biological activities such as radical scavenging and cytotoxicity. Here, we report on the isolation and identification of a new dermacozine compound, dermacozine M, the chemical structure of which was determined using 1D and 2D-NMR, and high resolution MS. A whole genome sequence of the strain contained six secondary metabolite-biosynthetic gene clusters (BGCs), including one responsible for the biosynthesis of a family of phenazine compounds. A pathway leading to the biosynthesis of dermacozines is proposed. Bioinformatic analyses of key stress-related genes provide an insight into how the organism adapted to the environmental conditions that prevail in the deep-sea. View Full-Text
Keywords: Mariana Trench; Dermacoccus abyssi MT1.1T; dermacozines; genome sequencing; biosynthetic gene clusters Mariana Trench; Dermacoccus abyssi MT1.1T; dermacozines; genome sequencing; biosynthetic gene clusters
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Abdel-Mageed, W.M.; Juhasz, B.; Lehri, B.; Alqahtani, A.S.; Nouioui, I.; Pech-Puch, D.; Tabudravu, J.N.; Goodfellow, M.; Rodríguez, J.; Jaspars, M.; Karlyshev, A.V. Whole Genome Sequence of Dermacoccus abyssi MT1.1 Isolated from the Challenger Deep of the Mariana Trench Reveals Phenazine Biosynthesis Locus and Environmental Adaptation Factors. Mar. Drugs 2020, 18, 131.

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