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Article

Probing Anti-Proliferative 24-Homoscalaranes from a Sponge Lendenfeldia sp.

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Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
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Doctoral Degree Program in Marine Biotechnology, Academia Sinica, Taipei 11529, Taiwan
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National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan
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Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan
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Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
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Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan
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Department of Marine Recreation, National Penghu University of Science and Technology, Penghu 88046, Taiwan
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Institute of Chemistry, Academia Sinica, Taipei 11529, Taiwan
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Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan
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Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
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Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(2), 76; https://doi.org/10.3390/md18020076
Received: 30 December 2019 / Revised: 16 January 2020 / Accepted: 22 January 2020 / Published: 24 January 2020
In the current study, an NMR spectroscopic pattern-based procedure for probing scalarane derivatives was performed and four new 24-homoscalaranes, lendenfeldaranes A–D (14), along with three known compounds, 12α-acetoxy-22-hydroxy-24-methyl-24-oxoscalar-16-en- 25-al (5), felixin F (6), and 24-methyl-12,24,25-trioxoscalar-16-en-22-oic acid (7) were isolated from the sponge Lendenfeldia sp. The structures of scalaranes 17 were elucidated on the basis of spectroscopic analysis. Scalaranes 17 were further evaluated for their cytotoxicity toward a series of human cancer cell lines and the results suggested that 5 and 7 dominated in the anti- proliferative activity of the extract. The 18-aldehyde functionality was found to play a key role in their activity. View Full-Text
Keywords: scalarane; sesterterpenoid; anti-proliferation; Lendenfeldia scalarane; sesterterpenoid; anti-proliferation; Lendenfeldia
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MDPI and ACS Style

Peng, B.-R.; Lai, K.-H.; Chen, Y.-Y.; Su, J.-H.; Huang, Y.M.; Chen, Y.-H.; Lu, M.-C.; Yu, S.S.-F.; Duh, C.-Y.; Sung, P.-J. Probing Anti-Proliferative 24-Homoscalaranes from a Sponge Lendenfeldia sp. Mar. Drugs 2020, 18, 76. https://doi.org/10.3390/md18020076

AMA Style

Peng B-R, Lai K-H, Chen Y-Y, Su J-H, Huang YM, Chen Y-H, Lu M-C, Yu SS-F, Duh C-Y, Sung P-J. Probing Anti-Proliferative 24-Homoscalaranes from a Sponge Lendenfeldia sp. Marine Drugs. 2020; 18(2):76. https://doi.org/10.3390/md18020076

Chicago/Turabian Style

Peng, Bo-Rong, Kuei-Hung Lai, You-Ying Chen, Jui-Hsin Su, Yusheng M. Huang, Yu-Hsin Chen, Mei-Chin Lu, Steve S.-F. Yu, Chang-Yih Duh, and Ping-Jyun Sung. 2020. "Probing Anti-Proliferative 24-Homoscalaranes from a Sponge Lendenfeldia sp." Marine Drugs 18, no. 2: 76. https://doi.org/10.3390/md18020076

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